Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | REN | P00797 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 4/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6043263 | 0.88 | MAPT (0.40) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL7577186 | 0.85 | REN (0.52) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| Bromide SCHEMBL7563739 | 0.84 | REN (0.52) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6042729 | 0.82 | REN (0.55) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6041547 | 0.82 | MAPT (0.43) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL6042439 | 0.81 | MAPT (0.42) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL7562786 | 0.79 | FFAR1 (0.42) | FFAR1REN | |
| SCHEMBL6042838 | 0.78 | MAPT (0.44) | MAPTNPC1RAB9ASMN1; SMN2TSHR | |
| SCHEMBL7563407 | 0.77 | REN (0.34) | REN | |
| SCHEMBL7563412 | 0.77 | REN (0.34) | REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076440-A2 | METHODS OF TREATING ALZHEIMER'S DISEASE WITH PIPERIDIN DERIVATES | ELAN PHARMACEUTICALS, INC. (US) | 2002-10-03 | — | — | WO | disclosed |