Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA1 | P00915 | 1/20 | 0.61 |
| ▸ | CA2 | P00918 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | GFER | P55789 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | WDR5 | P61964 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | ITGA1 | P56199 | 1/20 | 0.50 |
| ▸ | ING2 | Q9H160 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ATIC | P31939 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594857 | 0.83 | CA1 (0.54) | HTTCA12CA1CA2CA9 | |
| SCHEMBL7574036 | 0.81 | PKM (0.68) | HTTGAAIDO1MEN1KMT2A | |
| SCHEMBL23109349 | 0.80 | CA1 (0.65) | HTTCA1CA2CA9MEN1 | |
| SCHEMBL7577405 | 0.80 | PTPRC (0.60) | CA12CA1CA2CA9GAA | |
| SCHEMBL15482013 | 0.78 | HDAC8 (0.71) | HTTCA12CA1CA2CA9 | |
| SCHEMBL9997330 | 0.78 | MCL1 (0.70) | CA12CA1CA2CA9GAA | |
| SCHEMBL7932062 | 0.78 | CA12 (0.73) | HTTCA12CA1CA2CA9 | |
| SCHEMBL3715141 | 0.77 | CA12 (0.75) | CA12CA1CA2CA9GAA | |
| SCHEMBL893905 | 0.77 | CA12 (0.73) | CA12CA1CA2CA9GAA | |
| SCHEMBL95742 | 0.76 | CA12 (0.71) | HTTCA12CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |