Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.68 |
| ▸ | LMNA | P02545 | 4/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.63 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.63 |
| ▸ | HTT | P42858 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | IDO1 | P14902 | 3/20 | 0.60 |
| ▸ | RAB9A | P51151 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | GFER | P55789 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594239 | 0.87 | PKM (0.61) | PKMLMNASMN1; SMN2MAPK1HTT | |
| SCHEMBL7577405 | 0.81 | PTPRC (0.60) | LMNASMN1; SMN2MAPK1MEN1KMT2A | |
| SCHEMBL7837467 | 0.81 | LMNA (0.63) | PKMLMNASMN1; SMN2MAPK1ALOX15 | |
| SCHEMBL7577210 | 0.81 | HTT (0.62) | HTTMEN1KMT2AIDO1GAA | |
| SCHEMBL7659979 | 0.81 | HTT (0.54) | SMN1; SMN2HTTMEN1KMT2ARAB9A | |
| SCHEMBL22066232 | 0.80 | PKM (0.77) | PKMLMNASMN1; SMN2MAPK1ALOX15 | |
| SCHEMBL23109349 | 0.78 | CA1 (0.65) | HTTMEN1KMT2AALDH1A1 | |
| SCHEMBL3402411 | 0.78 | MEN1 (0.91) | PKMMAPK1MEN1KMT2AIDO1 | |
| SCHEMBL9365750 | 0.78 | PKM (0.73) | PKMLMNASMN1; SMN2MAPK1MEN1 | |
| SCHEMBL15705234 | 0.78 | IDO1 (0.76) | PKMLMNASMN1; SMN2MAPK1ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1239852-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | Arrow Therapeutics Limited (GB) | 2002-09-18 | — | — | EP | disclosed |
| WO-2001028537-A2 | BISSULFONAMIDE DERIVATIVES AS ENZYME INHIBITORS | ARROW THERAPEUTICS LIMITED (GB) | 2001-04-26 | — | — | WO | disclosed |