Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | AKR1B1 | P15121 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.35 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.32 |
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | HTT | P42858 | 4/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | RAB9A | P51151 | 3/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7581125 | 0.89 | LMNA (0.36) | CYP3A4AKR1B1KMT2AMEN1LMNA | |
| SCHEMBL7584357 | 0.80 | CYP3A4 (0.47) | CYP3A4AKR1B1KMT2AMEN1LMNA | |
| SCHEMBL8504948 | 0.78 | ALDH1A1 (0.37) | CYP3A4KMT2AMEN1LMNAKDM4E | |
| SCHEMBL7580853 | 0.77 | CYP3A4 (0.41) | CYP3A4AKR1B1KDM4ECYP2C9CYP1A2 | |
| SCHEMBL7586143 | 0.77 | KMT2A (0.47) | CYP3A4AKR1B1KMT2AMEN1LMNA | |
| SCHEMBL8904617 | 0.70 | AKR1B1 (0.39) | AKR1B1KMT2AMEN1LMNAKDM4E | |
| SCHEMBL7588896 | 0.70 | CYP3A4 (0.42) | CYP3A4KMT2AMEN1LMNAKDM4E | |
| SCHEMBL8907157 | 0.69 | LMNA (0.35) | AKR1B1KMT2AMEN1LMNAKDM4E | |
| SCHEMBL8504953 | 0.69 | ALDH1A1 (0.38) | CYP3A4KMT2AMEN1LMNAKDM4E | |
| SCHEMBL7583160 | 0.69 | KMT2A (0.42) | CYP3A4AKR1B1KMT2AMEN1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0810218-B1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | HOFFMANN LA ROCHE (CH) | 2002-12-04 | — | — | EP | disclosed |
| EP-0810218-A1 | 6-Benzyl-2H-pyridazin-3-one derivatives,their preparation and their use as inhibitors of prostaglandin G/H synthase I and II (COX I and COX II) | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-03 | — | — | EP | disclosed |