Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 12/20 | 0.48 |
| ▸ | CTSL | P07711 | 2/20 | 0.48 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | CTSK | P43235 | 2/20 | 0.48 |
| ▸ | PRSS8 | Q16651 | 2/20 | 0.46 |
| ▸ | MMP3 | P08254 | 3/20 | 0.42 |
| ▸ | MMP1 | P03956 | 2/20 | 0.42 |
| ▸ | MMP2 | P08253 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 1/20 | 0.41 |
| ▸ | CES1 | P23141 | 1/20 | 0.41 |
| ▸ | DAGLA | Q9Y4D2 | 1/20 | 0.41 |
| ▸ | REN | P00797 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6462739 | 0.86 | CTSS (0.49) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6061690 | 0.86 | CTSS (0.49) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL7046177 | 0.86 | CTSS (0.49) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6061583 | 0.85 | PRSS8 (0.51) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6062668 | 0.84 | CTSS (0.50) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6464127 | 0.84 | CTSS (0.49) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6467344 | 0.84 | PRSS8 (0.45) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL5520928 | 0.83 | CTSS (0.45) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL6461909 | 0.82 | EPHX2 (0.49) | CTSSCTSLCTSBCTSKPRSS8 | |
| SCHEMBL7047088 | 0.81 | CTSS (0.62) | CTSSCTSLCTSBCTSKPRSS8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1161422-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2001-12-12 | — | — | EP | disclosed |
| WO-2000055144-A1 | AMINE DERIVATIVES AS PROTEASE INHIBITORS | AXYS PHARMACEUTICALS, INC. (US) | 2000-09-21 | — | — | WO | disclosed |