Lactofen

Lactofen

SCHEMBL7580388

CCNc1nc(NC(C)(C)C)nc(SC)n1.CCOC(=O)C(C)OC(=O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-].O=C(O)CNCP(=O)(O)O

nearest known ligand 0.42

Full drug profile on Sugi Atlas →

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.42
MEN1 O00255 2/20 0.42
KMT2A Q03164 2/20 0.42
TTR P02766 1/20 0.42
PPOX P50336 1/20 0.42
TSHR P16473 1/20 0.33
FFAR1 O14842 2/20 0.31
PYGL P06737 1/20 0.31
MAPT P10636 1/20 0.31
EGFR P00533 1/20 0.30
ERBB2 P04626 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Lactofen SCHEMBL7578077 0.95 TDP1 (0.41) TDP1MEN1KMT2ATTRPPOX
Terbutryne SCHEMBL7580867 0.91 KMT2A (0.43) TDP1MEN1KMT2ATTRPPOX
Lactofen SCHEMBL7582057 0.91 MEN1 (0.47) TDP1MEN1KMT2ATTRPPOX
Acifluorfen SCHEMBL7575930 0.91 KMT2A (0.53) TDP1MEN1KMT2ATTRPPOX
Lactofen SCHEMBL7587436 0.89 TDP1 (0.42) TDP1MEN1KMT2ATTRPPOX
Lactofen SCHEMBL7581472 0.89 MEN1 (0.45) TDP1MEN1KMT2ATTRPPOX
Lactofen SCHEMBL7581111 0.89 MEN1 (0.42) TDP1MEN1KMT2ATTRPPOX
Lactofen SCHEMBL7589255 0.88 TDP1 (0.41) TDP1MEN1KMT2ATTRPPOX
Oxyfluorfen SCHEMBL7584174 0.88 KMT2A (0.42) TDP1MEN1KMT2ATTRPPOX
Terbutryne SCHEMBL7580879 0.88 FFAR1 (0.35) TDP1MEN1KMT2ATTRPPOX

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT TDP1 1969/4885MEN1 4274/4885KMT2A 2099/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.