Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Propylene Glycol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | SPHK1 | Q9NYA1 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | GMNN | O75496 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | THPO | P40225 | 1/20 | 0.44 |
| ▸ | MTOR | P42345 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CETP | P11597 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.39 |
| ▸ | PLA2G1B | P04054 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Propylene Glycol SCHEMBL5880612 | 0.92 | LMNA (0.50) | LMNACYP2D6SPHK1MAPTGMNN | |
| Propylene Glycol SCHEMBL5880645 | 0.92 | LMNA (0.50) | LMNACYP2D6SPHK1MAPTGMNN | |
| Propylene Glycol SCHEMBL5880654 | 0.92 | LMNA (0.50) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL344908 | 0.92 | SPHK1 (0.48) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL10181292 | 0.92 | SPHK1 (0.48) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL10276905 | 0.92 | SPHK1 (0.48) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL4058309 | 0.92 | SPHK1 (0.48) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL27841408 | 0.92 | SPHK1 (0.48) | LMNACYP2D6SPHK1MAPTGMNN | |
| Glycerin SCHEMBL8149754 | 0.91 | USP2 (0.46) | LMNACYP2D6SPHK1MAPTGMNN | |
| SCHEMBL6668019 | 0.81 | FFAR1 (0.45) | LMNAMAPTGMNNPOLBBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1237532-A2 | ULTRAVIOLET RADIATION ABSORBING WAXES USEFUL IN COSMETIC COMPOSITIONS | The C.P. Hall Company (US) | 2002-09-11 | — | — | EP | disclosed |
| WO-2001041715-A2 | ULTRAVIOLET RADIATION ABSORBING WAXES USEFUL IN COSMETIC COMPOSITIONS | THE C.P. HALL COMPANY (US) | 2001-06-14 | — | — | WO | disclosed |