Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.49 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | SUV39H2 | Q9H5I1 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.46 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585050 | 0.90 | MAPT (0.47) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL23784871 | 0.87 | MAPT (0.57) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL7585009 | 0.87 | MAPT (0.45) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL30930919 | 0.86 | MAPT (0.51) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL19001559 | 0.86 | MAPT (0.51) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL7582943 | 0.86 | LMNA (0.51) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL805892 | 0.86 | MAPT (0.53) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL17884463 | 0.86 | MAPT (0.53) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL24847031 | 0.85 | MAPT (0.56) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 | |
| SCHEMBL7585738 | 0.85 | MAPT (0.47) | MAPTLMNAALDH1A1SMN1; SMN2PDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |