Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.46 |
| ▸ | SUV39H2 | Q9H5I1 | 2/20 | 0.46 |
| ▸ | ESRRB | O95718 | 1/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.45 |
| ▸ | ESRRA | P11474 | 1/20 | 0.45 |
| ▸ | ESRRG | P62508 | 1/20 | 0.45 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.45 |
| ▸ | NAMPT | P43490 | 1/20 | 0.45 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7589851 | 0.87 | LMNA (0.43) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL7581350 | 0.86 | MAPT (0.53) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL4941010 | 0.84 | LMNA (0.51) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL24847031 | 0.83 | MAPT (0.56) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL26604111 | 0.82 | MAPT (0.54) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL24848428 | 0.82 | ABCB1 (0.55) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL5683429 | 0.81 | MAPT (0.57) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL5683408 | 0.81 | ABCB1 (0.60) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL2386587 | 0.81 | SUV39H2 (0.55) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 | |
| SCHEMBL30726275 | 0.81 | SUV39H2 (0.55) | LMNAMAPTALDH1A1SMN1; SMN2GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |