Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 2/20 | 0.35 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.35 |
| ▸ | WNT1 | P04628 | 1/20 | 0.35 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | CHRNB2 | P17787 | 8/20 | 0.34 |
| ▸ | CHRNA4 | P43681 | 8/20 | 0.34 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.34 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 7/20 | 0.34 |
| ▸ | NTMT1 | Q9BV86 | 1/20 | 0.33 |
| ▸ | KDM1A | O60341 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128777 | 1.00 | PTPN1 (0.35) | PTPN1PTPN11WNT1DYRK1ACHRNB2 | |
| SCHEMBL7117126 | 0.86 | PTPN1 (0.49) | PTPN1PTPN11CHRNB2CHRNA4USP30 | |
| SCHEMBL7595144 | 0.86 | PTPN1 (0.49) | PTPN1PTPN11CHRNB2CHRNA4USP30 | |
| SCHEMBL7583880 | 0.85 | TAS1R3 (0.39) | PTPN1PTPN11CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7218955 | 0.85 | TAS1R3 (0.39) | PTPN1PTPN11CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7124514 | 0.84 | ACKR3 (0.37) | PTPN1PTPN11WNT1DYRK1ACHRNB2 | |
| SCHEMBL7225519 | 0.83 | PTPN1 (0.38) | PTPN1PTPN11WNT1DYRK1ACHRNB2 | |
| SCHEMBL7125448 | 0.83 | CHRNB2 (0.37) | PTPN1PTPN11WNT1DYRK1ACHRNB2 | |
| SCHEMBL7118038 | 0.83 | PTPN1 (0.38) | PTPN1PTPN11CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL7127049 | 0.83 | KDM4E (0.46) | PTPN1PTPN11CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002015662-A2 | QUINUCLIDINE-SUBSTITUTED HETEROARYL MOIETIES FOR TREATMENT OF DISEASE (NICOTINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS | PHARMACIA & UPJOHN COMPANY (US) | 2002-02-28 | — | — | WO | claimed |