Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.72 |
| ▸ | POLB | P06746 | 1/20 | 0.72 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.72 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.61 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | USP2 | O75604 | 1/20 | 0.56 |
| ▸ | GAA | P10253 | 1/20 | 0.56 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.56 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.56 |
| ▸ | CA12 | O43570 | 3/20 | 0.55 |
| ▸ | CA1 | P00915 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 3/20 | 0.55 |
| ▸ | CA7 | P43166 | 3/20 | 0.55 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5527283 | 0.92 | POLB (0.72) | TDP1POLBL3MBTL1KDM4ESRD5A2 | |
| SCHEMBL5055341 | 0.90 | MEN1 (0.70) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL27618688 | 0.85 | ALDH1A1 (0.63) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL31298798 | 0.83 | ALDH1A1 (0.70) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL177949 | 0.83 | ALDH1A1 (0.70) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL29360039 | 0.82 | AKR1C3 (0.76) | TDP1POLBL3MBTL1KDM4ESRD5A2 | |
| SCHEMBL28021862 | 0.82 | MEN1 (0.75) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL63564 | 0.82 | AKR1C3 (0.76) | TDP1POLBL3MBTL1KDM4ESRD5A2 | |
| Hydrochloric Acid SCHEMBL11161670 | 0.81 | ALDH1A1 (0.67) | TDP1POLBL3MBTL1KDM4EMEN1 | |
| SCHEMBL31390818 | 0.81 | ALDH1A1 (0.67) | TDP1POLBL3MBTL1KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1279053-C | Modulators for beta-amyloid peptide aggregation comprising D-amino acids | PRAECIS PHARM INC (US) | 2006-10-11 | — | — | CN | disclosed |
| EP-1263454-A2 | METHODS FOR ENHANCING THE BIOAVAILABILITY OF A DRUG | Praecis Pharmaceuticals Incorporated (US) | 2002-12-11 | — | — | EP | disclosed |
| WO-2000052048-A9 | MODULATORS OF BETA-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | PRAECIS PHARM INC (US) | 2002-04-11 | — | — | WO | disclosed |
| WO-2001058470-A2 | METHODS FOR ENHANCING THE BIOAVAILABILITY OF A DRUG | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2001-08-16 | — | — | WO | disclosed |