Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 6/20 | 0.38 |
| ▸ | SRC | P12931 | 6/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | GUSB | P08236 | 1/20 | 0.36 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.36 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.36 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.36 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.36 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.36 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | STK10 | O94804 | 2/20 | 0.34 |
| ▸ | EGFR | P00533 | 2/20 | 0.34 |
| ▸ | SLK | Q9H2G2 | 2/20 | 0.34 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.34 |
| ▸ | STK25 | O00506 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584087 | 0.81 | GUSB (0.39) | FGFR1SRCGUSBPDE3BPDE3A | |
| SCHEMBL29536840 | 0.80 | FGFR1 (0.45) | FGFR1SRCPSEN1PSEN2APH1B | |
| SCHEMBL5659394 | 0.80 | FGFR1 (0.45) | FGFR1SRCPSEN1PSEN2APH1B | |
| SCHEMBL19817042 | 0.69 | SIK2 (0.40) | FGFR1SRCPSEN1PSEN2APH1B | |
| SCHEMBL14370847 | 0.68 | SIK2 (0.47) | LMNAGUSBABL1STK10SLK | |
| SCHEMBL29536534 | 0.68 | SIK2 (0.47) | LMNAGUSBABL1STK10SLK | |
| SCHEMBL5619944 | 0.65 | SRC (0.56) | FGFR1SRCABL1EGFRPDGFRB | |
| SCHEMBL16986359 | 0.65 | DHFR (0.41) | FGFR1SRCGUSBPDE3BPDE3A | |
| SCHEMBL14875515 | 0.64 | WEE1 (0.47) | FGFR1SRCLMNAHPGDPSEN1 | |
| SCHEMBL14161489 | 0.64 | RIPK2 (0.46) | FGFR1SRCLMNAABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076396-A2 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |