Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | DAO | P14920 | 2/20 | 0.38 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.38 |
| ▸ | YES1 | P07947 | 2/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.38 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.37 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.35 |
| ▸ | CACNG8 | Q8WXS5 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.34 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.34 |
| ▸ | WEE1 | P30291 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585252 | 0.81 | FGFR1 (0.38) | GUSBPDE3BPDE3AYES1EPHB4 | |
| SCHEMBL7592096 | 0.71 | FGFR1 (0.54) | SRCFGFR1ABL1PDGFRBPDGFRA | |
| SCHEMBL16986359 | 0.68 | DHFR (0.41) | GUSBPDE3BPDE3ASRCFGFR1 | |
| SCHEMBL5619944 | 0.68 | SRC (0.56) | SRCFGFR1ABL1PDGFRBPDGFRA | |
| SCHEMBL5659394 | 0.65 | FGFR1 (0.45) | YES1EPHB4SRCFGFR1ABL1 | |
| SCHEMBL29536840 | 0.65 | FGFR1 (0.45) | YES1EPHB4SRCFGFR1ABL1 | |
| SCHEMBL6643371 | 0.65 | FGFR1 (0.43) | GUSBDAOPDE3BPDE3ASRC | |
| SCHEMBL14161489 | 0.64 | RIPK2 (0.46) | SRCFGFR1ABL1PDGFRBPDGFRA | |
| SCHEMBL16986331 | 0.63 | FGFR1 (0.61) | SRCFGFR1ABL1PDGFRBPDGFRA | |
| SCHEMBL6639245 | 0.63 | FGFR1 (0.53) | SRCFGFR1GRIA1CACNG8ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002076396-A2 | COMPOUNDS USEFUL AS KINASE INHIBITORS FOR THE TREATMENT OF HYPERPROLIFERATIVE DISEASES | SMITHKLINE BEECHAM CORPORATION (US) | 2002-10-03 | — | — | WO | disclosed |