Acifluorfen

Acifluorfen

SCHEMBL7585372

COc1nc(C)nc(NC(=O)NS(=O)(=O)c2ccsc2C(=O)O)n1.O=C(O)CNCP(=O)(O)O.O=C(O)c1cc(Oc2ccc(C(F)(F)F)cc2Cl)ccc1[N+](=O)[O-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 2/20 0.46
MEN1 O00255 1/20 0.46
TTR P02766 1/20 0.46
PPOX P50336 1/20 0.46
KMT2A Q03164 1/20 0.46
PARP14 Q460N5 1/20 0.33
EDNRA P25101 1/20 0.33
TBXA2R P21731 3/20 0.32
LMNA P02545 1/20 0.32
SMN1; SMN2 Q16637 1/20 0.32
PYGL P06737 1/20 0.31
FFAR1 O14842 1/20 0.31
PTPRG P23470 1/20 0.30
FBP1 P09467 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Fomesafen SCHEMBL7576459 0.96 TDP1 (0.41) TDP1MEN1TTRPPOXKMT2A
Acifluorfen SCHEMBL7584458 0.95 TDP1 (0.44) TDP1MEN1TTRPPOXKMT2A
Oxyfluorfen SCHEMBL7584787 0.93 MEN1 (0.38) TDP1MEN1TTRPPOXKMT2A
Glyphosate SCHEMBL7580074 0.93 TDP1 (0.39) TDP1MEN1TTRPPOXKMT2A
Acifluorfen SCHEMBL7577323 0.92 TDP1 (0.54) TDP1MEN1TTRPPOXKMT2A
Fomesafen SCHEMBL7582035 0.91 TDP1 (0.40) TDP1MEN1TTRPPOXKMT2A
Bifenox SCHEMBL7584962 0.90 TDP1 (0.45) TDP1MEN1TTRPPOXKMT2A
Thifensulfuron-Methyl SCHEMBL7581225 0.89 TDP1 (0.52) TDP1MEN1TTRPPOXKMT2A
Glyphosate SCHEMBL7577140 0.89 TDP1 (0.38) TDP1MEN1TTRPPOXKMT2A
Oxyfluorfen SCHEMBL7585610 0.89 MEN1 (0.36) TDP1MEN1TTRPPOXKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT TDP1 1969/4885MEN1 4274/4885TTR 1945/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.