Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.51 |
| ▸ | HTR2A | P28223 | 7/20 | 0.51 |
| ▸ | HTR1A | P08908 | 6/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.39 |
| ▸ | HRH1 | P35367 | 3/20 | 0.38 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7128893 | 0.84 | HTR2A (0.55) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7127886 | 0.81 | HTR1A (0.52) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7119229 | 0.80 | HTR2A (0.58) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7119324 | 0.80 | HTR2A (0.52) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7117583 | 0.78 | DRD2 (0.55) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7118961 | 0.78 | HTR2A (0.55) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7124105 | 0.78 | HTR1A (0.55) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7123026 | 0.76 | DRD2 (0.55) | DRD2HTR2AHTR1AKCNH2SLC6A4 | |
| SCHEMBL7121850 | 0.76 | HTR2A (0.56) | DRD2HTR2AHTR1ASLC6A4 | |
| SCHEMBL7120429 | 0.76 | DRD2 (0.52) | DRD2HTR2AHTR1AKCNH2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1246820-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2002-10-09 | — | — | EP | disclosed |
| WO-2001049683-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2001-07-12 | — | — | WO | disclosed |