Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 6/20 | 0.37 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | TLR9 | Q9NR96 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 4/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | XBP1 | P17861 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 4/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.34 |
| ▸ | MITF | O75030 | 2/20 | 0.34 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31206017 | 0.79 | CA12 (0.41) | NPC1ALDH1A1HTTNPSR1LMNA | |
| SCHEMBL4138614 | 0.77 | NPSR1 (0.42) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL30637352 | 0.77 | NPSR1 (0.42) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL1750195 | 0.77 | PARP1 (0.38) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL11127281 | 0.76 | NFE2L2 (0.32) | ALDH1A1MEN1KMT2A | |
| SCHEMBL27828077 | 0.76 | LMNA (0.36) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL6430723 | 0.76 | USP2 (0.41) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL22471636 | 0.75 | PARP1 (0.37) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL20606050 | 0.75 | LMNA (0.39) | TP53MAPTTLR9NPC1ALDH1A1 | |
| SCHEMBL1490042 | 0.75 | MTOR (0.37) | MAPTPARP1LMNASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 391 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3658552-B1 | PROCESS FOR PREPARING N-(5-((4-(4-((DIMETHYLAMINO)METHYL)-3-PHENYL-1H-PYRAZOL-1-YL)PYRIMIDIN-2-YL)AMINO)-4-METHOXY-2-MORPHOLINOPHENYL)ACRYLAMIDE BY REACTING THE CORRESPONDING AMINE WITH A 3-HALO-PROPIONYL CHLORIDE | YUHAN CORP (KR) | 2023-09-13 | — | — | EP | claimed |
| CN-111315742-B | Process for preparing aminopyrimidine derivatives | 株式会社 柳韩洋行 | 2023-09-01 | — | — | CN | claimed |
| US-11286253-B2 | Process for preparing aminopyrimidine derivatives | YUHAN CORPORATION (KR) | 2022-03-29 | — | — | US | claimed |
| US-10889578-B2 | Process for preparing aminopyrimidine derivatives | YUHAN CORPORATION (KR) | 2021-01-12 | — | — | US | claimed |
| CN-111315742-A | Improved process for preparing aminopyrimidine derivatives | 株式会社柳韩洋行 | 2020-06-19 | — | — | CN | claimed |
| EP-3658552-A1 | IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES | Yuhan Corporation (KR) | 2020-06-03 | — | — | EP | claimed |
| US-20200165236-A1 | IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES | YUHAN CORPORATION (KR) | 2020-05-28 | — | — | US | claimed |
| WO-2019022485-A1 | IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES | YUHAN CORPORATION (KR) | 2019-01-31 | — | — | WO | claimed |
| EP-4746963-A1 | MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-27 | — | — | EP | disclosed |
| EP-4743465-A1 | BICYCLIC MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | F. Hoffmann-La Roche AG (CH) | 2026-05-20 | — | — | EP | disclosed |
| CN-122039076-A | Preparation method of 2-methyl sulfoxide pyrimidine derivative | 石河子大学 | 2026-05-15 | — | — | CN | disclosed |
| EP-4725554-A2 | COMPOUNDS AND COMPOSITIONS FOR MODULATING EGFR MUTANT KINASE ACTIVITIES | Yuhan Corporation (KR) | 2026-04-15 | — | — | EP | disclosed |
| EP-4709723-A1 | ISOXAZOLIDINES AS RIPK1 INHIBITORS AND USE THEREOF | GENZYME CORPORATION (US) | 2026-03-18 | — | — | EP | disclosed |
| US-20260070927-A1 | INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | HOFFMANN-LA ROCHE INC. (US) | 2026-03-12 | — | — | US | disclosed |
| US-4118382-A | DYES FOR CELLULOSE, WOOL, SILK, POLYAMIDE, AND POLYURETHANE FIBERS | BAYER AKTIENGESELLSCHAFT (DE) | 1978-10-03 | — | — | US | disclosed |
| US-4089895-A | COUPLER FOR AZO DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1978-05-16 | — | — | US | disclosed |
| US-4065446-A | Reactive dyestuffs containing urea alkylene linkage between chromophore and reactive radical | BAYER AKTIENGESELLSCHAFT (DT) | 1977-12-27 | — | — | US | disclosed |
| US-4049704-A | AZO REACTIVE DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-09-20 | — | — | US | disclosed |
| US-3988310-A | FIBER-REACTIVE DYES; CELLULOSE | BAYER AKTIENGESELLSCHAFT (DT) | 1976-10-26 | — | — | US | disclosed |
| US-3957751-A | WATER-SOLUBLE REACTIVE DYESTUFFS OF THE MONOAZO SERIES CONTAINING AN ACTIVE METHYLENE COUPLING COMPONENT | HOECHST AKTIENGESELLSCHAFT (DT) | 1976-05-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200165236-A1 | IMPROVED PROCESS FOR PREPARING AMINOPYRIMIDINE DERIVATIVES | EGFR, ERBB2, ERBB4 | TP53 247/4885MAPT 3545/4885TLR9 3449/4885 |
| US-11286253-B2 | Process for preparing aminopyrimidine derivatives | EGFR, ERBB2, ABL1 | TP53 207/4885MAPT 3799/4885TLR9 3593/4885 |
| US-20260070927-A1 | INDAZOLE MACROCYCLES FOR THE TREATMENT OF AUTOIMMUNE DISEASE | MALT1, CCR1, CCR6 | TP53 2738/4885MAPT 4693/4885TLR9 2330/4885 |
| US-10889578-B2 | Process for preparing aminopyrimidine derivatives | EGFR, ERBB2, ABL1 | TP53 218/4885MAPT 3689/4885TLR9 3421/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.