Metolachor

Metolachor

SCHEMBL7585566

C#CCOc1cc(-n2nc(C(C)(C)C)oc2=O)c(Cl)cc1Cl.CCNc1nc(Cl)nc(NC(C)C)n1.CCc1cccc(C)c1N(C(=O)CCl)C(C)COC

nearest known ligand 0.36

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Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
PPOX P50336 13/20 0.36
KMT2A Q03164 4/20 0.36
MEN1 O00255 3/20 0.36
TDP1 Q9NUW8 2/20 0.36
NR1I2 O75469 1/20 0.36
MAPT P10636 2/20 0.34
ALDH1A1 P00352 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
KDM4E B2RXH2 1/20 0.30
TP53 P04637 1/20 0.30
TSHR P16473 1/20 0.30
MAPK1 P28482 1/20 0.30
HTT P42858 1/20 0.30
NPSR1 Q6W5P4 1/20 0.30
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Metolachor SCHEMBL7581715 0.95 PPOX (0.36) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7577921 0.94 PPOX (0.32) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7581434 0.92 PPOX (0.31) PPOXKMT2AMEN1TDP1NR1I2
Oxadiazon SCHEMBL7589728 0.92 PPOX (0.46) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7577066 0.91 PPOX (0.43) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7585141 0.90
Metolachor SCHEMBL7588150 0.90 PPOX (0.32) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7584967 0.88 PPOX (0.30) PPOXKMT2AMEN1TDP1NR1I2
Metolachor SCHEMBL7579641 0.88 PPOX (0.31) PPOXKMT2AMEN1TDP1NR1I2
Oxadiazon SCHEMBL7577216 0.87 PPOX (0.46) PPOXKMT2AMEN1TDP1NR1I2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20020004457-A1 Herbicidal composition SYNGENTA PARTICIPATIONS AG (CH) 2002-01-10 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20020004457-A1 Herbicidal composition PPOX, ALAD, DDT PPOX 1/4885KMT2A 2099/4885MEN1 4274/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.