Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | PKM | P14618 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.42 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11303623 | 0.87 | LMNA (0.56) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL29025770 | 0.81 | LMNA (0.61) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL11100536 | 0.81 | LMNA (0.50) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL1268888 | 0.79 | F2 (0.52) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL358399 | 0.76 | LMNA (0.62) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL5562226 | 0.76 | CHEK2 (0.54) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL2001474 | 0.75 | LMNA (0.47) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| Hydrochloric Acid SCHEMBL270477 | 0.74 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| Hydrochloric Acid SCHEMBL270476 | 0.74 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| Hydrochloric Acid SCHEMBL20291494 | 0.74 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101346355-B | Improved process for preparing salts of 4- (benzimidazolylmethylamino) -benzamidines | BOEHRINGER INGELHEIM INT | 2012-09-05 | — | — | CN | disclosed |
| CN-1972919-B | Method for producing 4-(benzimidazolylmethylamino)-benzamidines | BOEHRINGER INGELHEIM INT | 2012-06-27 | — | — | CN | disclosed |
| EP-1847534-B9 | Thiadiazoline derivatives for treating cancer | KYOWA HAKKO KIRIN CO LTD (JP) | 2012-03-21 | — | — | EP | disclosed |
| EP-1847534-B1 | Thiadiazoline derivatives for treating cancer | KYOWA HAKKO KIRIN CO LTD (JP) | 2011-06-22 | — | — | EP | disclosed |
| CN-1972919-A | Method for producing 4-(benzimidazolylmethylamino)-benzamidines | BOEHRINGER INGELHEIM INT (DE) | 2007-05-30 | — | — | CN | disclosed |