Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 2/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.54 |
| ▸ | RAB9A | P51151 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.50 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL20291494 | 0.98 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| Hydrochloric Acid SCHEMBL270476 | 0.98 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| Hydrochloric Acid SCHEMBL270477 | 0.98 | LMNA (0.66) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL29025770 | 0.86 | LMNA (0.61) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL15883889 | 0.84 | LMNA (0.59) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL22227972 | 0.83 | LMNA (0.61) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL15883906 | 0.81 | BCHE (0.58) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL11303623 | 0.81 | LMNA (0.56) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL19361299 | 0.81 | LMNA (0.56) | LMNACYP1A2CYP2D6CYP2C19BCHE | |
| SCHEMBL350139 | 0.80 | LMNA (0.54) | LMNACYP1A2CYP2D6CYP2C19BCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153674-B | Iminothiadiazine dioxide derivatives as inhibitors of plasmepsin V of plasmodium | UCB生物制药有限责任公司 | 2022-03-22 | — | — | CN | claimed |
| CN-109153674-B | Iminothiadiazine dioxide derivatives as inhibitors of plasmepsin V of plasmodium | UCB生物制药有限责任公司 | 2022-03-22 | — | — | CN | disclosed |
| US-20180319955-A1 | RUBBER COMPOSITION, AND PNEUMATIC TIRE USING SAME | BRIDGESTONE CORPORATION (JP) | 2018-11-08 | — | — | US | disclosed |
| US-10053553-B2 | Rubber composition, and pneumatic tire using same | BRIDGESTONE CORPORATION (JP) | 2018-08-21 | — | — | US | disclosed |
| EP-2960284-B1 | RUBBER COMPOSITION, AND PNEUMATIC TIRE USING SAME | BRIDGESTONE CORP (JP) | 2018-08-01 | — | — | EP | disclosed |
| CN-104955890-B | Rubber composition and use its pneumatic tire | 株式会社普利司通 | 2017-11-28 | — | — | CN | disclosed |
| EP-2740730-B1 | DIBENZOOXEPIN DERIVATIVE | KYOWA HAKKO KIRIN CO LTD (JP) | 2016-11-16 | — | — | EP | disclosed |
| EP-2960284-A1 | RUBBER COMPOSITION, AND PNEUMATIC TIRE USING SAME | Bridgestone Corporation (JP) | 2015-12-30 | — | — | EP | disclosed |
| US-20150361248-A1 | RUBBER COMPOSITION, AND PNEUMATIC TIRE USING SAME | OTSUKA CHEMICAL CO., LTD. (JP) | 2015-12-17 | — | — | US | disclosed |
| US-8969345-B2 | Dibenzooxepin derivative | KYOWA HAKKO KIRIN CO., LTD. (JP) | 2015-03-03 | — | — | US | disclosed |
| US-20100305096-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. | 2010-12-02 | — | — | US | disclosed |
| WO-2010138589-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2010138589-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | GENENTECH, INC. (US) | 2010-12-02 | — | — | WO | disclosed |
| WO-2007117778-A9 | QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS INC (US) | 2009-05-22 | — | — | WO | disclosed |
| EP-1986747-A2 | QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | Kalypsys, Inc. (US) | 2008-11-05 | — | — | EP | disclosed |
| US-20080139558-A1 | QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2008-06-12 | — | — | US | disclosed |
| WO-2007117778-A2 | QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | KALYPSYS, INC. (US) | 2007-10-18 | — | — | WO | disclosed |
| EP-1322620-A1 | BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS | Neurogen Corporation (US) | 2003-07-02 | — | — | EP | disclosed |
| US-20030055037-A1 | Benzimidazole and indole derivatives as CRF receptor modulators | NEUROGEN CORPORATION | 2003-03-20 | — | — | US | disclosed |
| WO-2002028839-A1 | BENZIMIDAZOLE AND INDOLE DERIVATIVES AS CRF RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2002-04-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080139558-A1 | QUINOLONES USEFUL AS INDUCIBLE NITRIC OXIDE SYNTHASE INHIBITORS | NOS2, NOS1, NQO2 | LMNA 2981/4885CYP1A2 54/4885CYP2D6 77/4885 |
| US-20030055037-A1 | Benzimidazole and indole derivatives as CRF receptor modulators | CRHR1, CRH, HTR4 | LMNA 915/4885CYP1A2 3645/4885CYP2D6 2517/4885 |
| US-20100305096-A1 | BICYCLIC PYRIMIDINE PI3K INHIBITOR COMPOUNDS SELECTIVE FOR P110 DELTA, AND METHODS OF USE | PIK3CA, PIK3R2, PIK3CD | LMNA 3229/4885CYP1A2 702/4885CYP2D6 2614/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.