Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 15/20 | 0.44 |
| ▸ | PDE4A | P27815 | 14/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 14/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 14/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7586055 | 0.91 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL7586053 | 0.88 | MEN1 (0.51) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL7585046 | 0.87 | MEN1 (0.50) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL10320513 | 0.81 | ALDH1A1 (0.41) | KMT2ALMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL20379847 | 0.80 | LMNA (0.43) | KMT2ALMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL332555 | 0.80 | PDE4A (0.45) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL31525333 | 0.78 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL20028646 | 0.77 | ALDH1A1 (0.47) | PDE4BPDE4APDE4CPDE4DKMT2A | |
| SCHEMBL23801993 | 0.77 | KMT2A (0.43) | KMT2ALMNAHPGDKDM4EALDH1A1 | |
| SCHEMBL20028645 | 0.74 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780375-B1 | 3-((5-substituted benzyl)amino)-2-phenylpiperidines as substance p antagonists | PFIZER (US) | 2002-09-11 | — | — | EP | disclosed |
| US-5789423-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS; GASTROINTESTINAL AND CENTRAL NERVOUS SYSTEM DISORDERS | PFIZER INC. (US) | 1998-08-04 | — | — | US | disclosed |
| EP-0780375-A1 | 3-((5-substituted benzyl)amino)-2-phenylpiperidines as substance p antagonists | PFIZER INC. (US) | 1997-06-25 | — | — | EP | disclosed |