Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | HSD17B3 | P37058 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sulfuric Acid SCHEMBL6232322 | 0.98 | POLB (0.40) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Ammonia Solution, Strong SCHEMBL29105388 | 0.90 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Iodide SCHEMBL28361954 | 0.87 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Bromide SCHEMBL1797567 | 0.87 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Hydrochloric Acid SCHEMBL3937688 | 0.87 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Bromide SCHEMBL4745574 | 0.87 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Iodide SCHEMBL3292671 | 0.87 | KDM1A (0.39) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Perchlorate SCHEMBL30120605 | 0.83 | POLB (0.37) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Ammonia Solution, Strong SCHEMBL8821900 | 0.80 | MAPT (0.36) | POLBNOTUMNPSR1TP53HSD17B3 | |
| Ammonia Solution, Strong SCHEMBL2675711 | 0.78 | ALDH1A1 (0.36) | POLBMAPTALDH1A1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689552-B1 | A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS | VOROTELIAK VICTOR (AU) | 2002-10-30 | — | — | EP | claimed |
| EP-0689552-A4 | A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS | VOROTELIAK VICTOR (AU) | 1997-07-02 | — | — | EP | claimed |
| EP-0689552-A1 | A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS | VOROTELIAK, Victor (AU) | 1996-01-03 | — | — | EP | claimed |
| WO-1994021687-A1 | A METHOD OF DETECTING RUPTURE OF THE AMNIOTIC MEMBRANES IN PREGANT MAMMALS | VOROTELIAK VICTOR (AU) | 1994-09-29 | — | — | WO | claimed |