Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP1 | P53582 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.45 |
| ▸ | HTR7 | P34969 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3822940 | 0.84 | METAP1 (0.68) | METAP1ACHESIGMAR1HTR7CYP19A1 | |
| Hydrochloric Acid SCHEMBL2126669 | 0.82 | METAP1 (0.68) | METAP1ACHESIGMAR1 | |
| SCHEMBL11026228 | 0.80 | CYP19A1 (0.49) | METAP1ACHESIGMAR1CYP19A1 | |
| SCHEMBL7305594 | 0.80 | CYP19A1 (0.50) | METAP1ACHESIGMAR1CYP19A1HTR2C | |
| Hydrochloric Acid SCHEMBL9425957 | 0.79 | CYP19A1 (0.49) | METAP1ACHESIGMAR1CYP19A1HTR2C | |
| SCHEMBL15700140 | 0.76 | ACHE (0.56) | METAP1ACHESIGMAR1HTR7CYP19A1 | |
| SCHEMBL2125675 | 0.75 | METAP1 (0.71) | METAP1ACHESIGMAR1CYP19A1 | |
| SCHEMBL8003063 | 0.75 | METAP1 (0.71) | METAP1ACHESIGMAR1CYP19A1 | |
| SCHEMBL7314737 | 0.74 | ACHE (0.49) | METAP1ACHESIGMAR1HTR7CYP19A1 | |
| SCHEMBL7337009 | 0.74 | CYP19A1 (0.43) | METAP1ACHESIGMAR1CYP19A1HTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0864559-B1 | Substituted amino compounds and their use as analgesic active substances | GRUENENTHAL GMBH (DE) | 2002-06-05 | — | — | EP | disclosed |
| US-6022895-A | Substituted amino compounds and their use as substances having an analgesic effect | GRUENENTHAL GMBH (DE) | 2000-02-08 | — | — | US | disclosed |
| EP-0864559-A1 | Substituted amino compounds and their use as analgesic active substances | Grünenthal GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |