Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A1 | P30531 | 4/20 | 0.33 |
| ▸ | SLC6A11 | P48066 | 3/20 | 0.33 |
| ▸ | SLC6A13 | Q9NSD5 | 3/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.32 |
| ▸ | SLC6A12 | P48065 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.32 |
| ▸ | GABRR1 | P24046 | 1/20 | 0.32 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2905562 | 1.00 | SLC6A1 (0.33) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| Hydrochloric Acid SCHEMBL8112201 | 0.98 | SLC6A1 (0.32) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| Hydrochloric Acid SCHEMBL7590833 | 0.98 | SLC6A1 (0.32) | SLC6A1SLC6A11SLC6A13TSHRLMNA | |
| SCHEMBL10753923 | 0.81 | — | — | |
| SCHEMBL8103030 | 0.81 | KDM4E (0.35) | — | |
| SCHEMBL1351693 | 0.81 | CHRM2 (0.33) | — | |
| SCHEMBL19209920 | 0.79 | SLC6A1 (0.31) | SLC6A1SLC6A11SLC6A13GABRA5GABRB2 | |
| SCHEMBL31031091 | 0.79 | CHRM2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL28060494 | 0.79 | CHRM2 (0.33) | — | |
| Hydrochloric Acid SCHEMBL27835399 | 0.79 | CHRM2 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2836485-B1 | CONFORMATIONALLY CONSTRAINED, FULLY SYNTHETIC MACROCYCLIC COMPOUNDS | POLYPHOR AG (CH) | 2018-01-10 | — | — | EP | claimed |
| EP-0803502-B1 | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives | LONZA AG (CH) | 2002-06-26 | — | — | EP | disclosed |
| EP-0744401-B1 | Process for the preparation of optically active 2-piperazine carboxylic acid derivatives | LONZA AG (CH) | 2001-11-21 | — | — | EP | disclosed |
| EP-1125930-A1 | Optically active piperazine-2-carboxylic acid derivatives and process for their preparation | LONZA AG (CH) | 2001-08-22 | — | — | EP | disclosed |
| EP-0756593-B1 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 2000-09-20 | — | — | EP | disclosed |
| EP-0803502-A2 | Process for the preparation of optically active piperazine-2-carboxylic acid derivatives | LONZA AG (CH) | 1997-10-29 | — | — | EP | disclosed |
| EP-0756593-A1 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 1997-02-05 | — | — | EP | disclosed |
| EP-0744401-A2 | Process of preparation of optically active 2-piperazine carboxylic acid | LONZA AG (CH) | 1996-11-27 | — | — | EP | disclosed |
| WO-1995029169-A2 | PROCESS FOR PREPARING 2-PIPERAZINE CARBOXYLIC ACID DERIVATIVES | LONZA AG (CH) | 1995-11-02 | — | — | WO | disclosed |