Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 1/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.33 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.33 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590011 | 1.00 | CNR2 (0.41) | CNR2CHRNA7SYKMAPTTRPA1 | |
| SCHEMBL7584122 | 0.90 | MAPT (0.38) | MAPTCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL7955784 | 0.90 | MAPT (0.38) | MAPTCYP1A2CYP2C19CYP3A4CYP2D6 | |
| SCHEMBL7585656 | 0.87 | CHRNA7 (0.43) | CNR2CHRNA7MAPTCHRM5CHRM1 | |
| SCHEMBL7585162 | 0.86 | CHRNA7 (0.42) | CNR2CHRNA7MAPTADORA2AADORA1 | |
| SCHEMBL7582663 | 0.85 | CHRNA7 (0.41) | CHRNA7MAPTCYP2C19CYP2D6ADORA2A | |
| SCHEMBL7586476 | 0.84 | CHRNA7 (0.40) | CHRNA7MAPTCYP2C19CYP2D6ADORA2A | |
| SCHEMBL7584430 | 0.84 | CHRNA7 (0.47) | CHRNA7SYKMAPTSIGMAR1ADORA2A | |
| SCHEMBL7583655 | 0.83 | CHRNA7 (0.39) | CHRNA7CYP2C19CYP2D6ADORA2AADORA1 | |
| SCHEMBL7582493 | 0.83 | HTR7 (0.42) | CHRNA7CHRM5CHRM1CHRM3HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |