Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.35 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.34 |
| ▸ | KCNK2 | O95069 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7584122 | 1.00 | MAPT (0.38) | MAPTTP53MAPK1DRD2DRD3 | |
| SCHEMBL7590011 | 0.90 | CNR2 (0.41) | MAPTTP53CACNA1GADRA1DADRA1A | |
| SCHEMBL7587203 | 0.90 | CNR2 (0.41) | MAPTTP53CACNA1GADRA1DADRA1A | |
| SCHEMBL7583679 | 0.88 | DRD2 (0.44) | MAPTDRD2DRD3NPSR1HRH4 | |
| SCHEMBL7582205 | 0.87 | DRD2 (0.38) | MAPTTP53MAPK1DRD2DRD3 | |
| SCHEMBL7587432 | 0.86 | MAPT (0.39) | MAPTDRD2DRD3NPSR1HRH4 | |
| SCHEMBL7589752 | 0.84 | DRD2 (0.36) | MAPTDRD2DRD3NPSR1HRH4 | |
| Hydrochloric Acid SCHEMBL7585021 | 0.83 | DRD2 (0.35) | MAPTDRD2DRD3NPSR1HRH4 | |
| Hydrochloric Acid SCHEMBL7584884 | 0.83 | DRD2 (0.35) | MAPTDRD2DRD3NPSR1HRH4 | |
| SCHEMBL7585740 | 0.79 | DRD2 (0.44) | DRD2DRD3ADRA1AGAASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |