Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB1 | P08588 | 9/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | CHRNB2 | P17787 | 7/20 | 0.62 |
| ▸ | CHRNA4 | P43681 | 7/20 | 0.62 |
| ▸ | HTR3E | A5X5Y0 | 3/20 | 0.52 |
| ▸ | HTR3B | O95264 | 3/20 | 0.52 |
| ▸ | HTR3A | P46098 | 3/20 | 0.52 |
| ▸ | HTR3D | Q70Z44 | 3/20 | 0.52 |
| ▸ | HTR3C | Q8WXA8 | 3/20 | 0.52 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7590675 | 0.81 | CHRNB2 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7587237 | 0.81 | CHRNB2 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7583755 | 0.81 | CHRNB2 (0.48) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL11530002 | 0.79 | ADRB1 (0.67) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9230825 | 0.79 | CHRNB2 (0.46) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7590671 | 0.78 | CHRNB2 (0.45) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7590631 | 0.78 | ADRB1 (0.46) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7584867 | 0.78 | CHRNB2 (0.45) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL4661355 | 0.78 | ADRB1 (0.64) | ADRB1CHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL11530582 | 0.78 | ADRB1 (0.64) | ADRB1CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| US-5849912-A | Biphenyl derivatives | EISAI CO., LTD. (JP) | 1998-12-15 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |