Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | BCHE | P06276 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | MAOB | P27338 | 2/20 | 0.55 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.54 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.54 |
| ▸ | GCGR | P47871 | 1/20 | 0.52 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.51 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.51 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592082 | 0.90 | ABCG2 (0.61) | MAPTLMNANPC1RAB9AMAOB | |
| SCHEMBL7591200 | 0.90 | MAPT (0.60) | MAPTLMNANPC1RAB9AMAOB | |
| SCHEMBL7594006 | 0.85 | ABCG2 (0.59) | MAPTLMNAHPGDABCB1KDM4E | |
| SCHEMBL29003694 | 0.83 | F3 (0.55) | MAPTLMNABCHERAB9AMAOB | |
| SCHEMBL30274993 | 0.83 | F3 (0.55) | MAPTLMNABCHERAB9AMAOB | |
| SCHEMBL7594011 | 0.79 | KDM4E (0.62) | MAPTLMNAHPGDGCGRABCB1 | |
| SCHEMBL7588254 | 0.78 | ABCG2 (0.60) | MAPTLMNAMAOBHPGDCYP3A4 | |
| SCHEMBL16066037 | 0.78 | ABCG2 (0.60) | MAPTLMNAMAOBHPGDCYP3A4 | |
| SCHEMBL9915666 | 0.78 | CYP1B1 (0.54) | MAPTLMNANPC1BCHERAB9A | |
| SCHEMBL27586221 | 0.77 | KDM4E (0.60) | MAPTLMNAHPGDKDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1253141-A1 | Substituted carbazoles as tubulin polymerization inhibitors and their use for the treatment of cancer | Aventis Pharma S.A. (FR) | 2002-10-30 | — | — | EP | disclosed |