Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.60 |
| ▸ | RAB9A | P51151 | 5/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | NPC1 | O15118 | 3/20 | 0.60 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.60 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.53 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.50 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.50 |
| ▸ | RELA | Q04206 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7592082 | 0.92 | ABCG2 (0.61) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7588249 | 0.90 | MAPT (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30274993 | 0.85 | F3 (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2TNFRSF1A | |
| SCHEMBL29003694 | 0.85 | F3 (0.55) | MAPTALDH1A1RAB9ASMN1; SMN2TNFRSF1A | |
| SCHEMBL7594006 | 0.82 | ABCG2 (0.59) | MAPTALDH1A1SMN1; SMN2TNFRSF1ALMNA | |
| SCHEMBL7591205 | 0.80 | ABCG2 (0.61) | MAPTALDH1A1RAB9ANPC1TNFRSF1A | |
| SCHEMBL7592084 | 0.78 | ABCG2 (0.61) | MAPTALDH1A1RAB9AMEN1KMT2A | |
| SCHEMBL23781994 | 0.77 | MAPT (0.60) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL30000178 | 0.77 | MAPT (0.60) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL7188106 | 0.77 | MAPT (1.00) | MAPTALDH1A1RAB9ASMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1253141-A1 | Substituted carbazoles as tubulin polymerization inhibitors and their use for the treatment of cancer | Aventis Pharma S.A. (FR) | 2002-10-30 | — | — | EP | disclosed |