SCHEMBL7589035

SCHEMBL7589035

C=C1[C@@H](c2ccc(C3CCC3)cc2)[C@@](C)(c2ccc(F)cc2F)NC(=N)N1C

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AKR1A1 P14550 1/20 0.35
AKR1B1 P15121 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7581538 0.96 AKR1A1 (0.33) AKR1A1AKR1B1
SCHEMBL7570124 0.88 AKR1A1 (0.39) AKR1A1AKR1B1
SCHEMBL13054067 0.88 AKR1A1 (0.39) AKR1A1AKR1B1
SCHEMBL7589121 0.84 MEN1 (0.35)
SCHEMBL18294773 0.84 MEN1 (0.35)
SCHEMBL18294778 0.84 TP53 (0.31)
SCHEMBL7579947 0.84 TP53 (0.31)
SCHEMBL7583745 0.84
SCHEMBL13055102 0.83 AKR1A1 (0.37) AKR1A1AKR1B1
SCHEMBL7549590 0.83 AKR1A1 (0.37) AKR1A1AKR1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8183252-B2 Heterocyclic aspartyl protease inhibitors SCHERING CORPORATION (US) 2012-05-22 US disclosed