Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 17/20 | 0.64 |
| ▸ | MMP2 | P08253 | 10/20 | 0.60 |
| ▸ | MMP3 | P08254 | 9/20 | 0.60 |
| ▸ | MMP8 | P22894 | 5/20 | 0.56 |
| ▸ | MMP9 | P14780 | 5/20 | 0.56 |
| ▸ | MMP7 | P09237 | 4/20 | 0.56 |
| ▸ | FCER2 | P06734 | 3/20 | 0.56 |
| ▸ | ADAM17 | P78536 | 2/20 | 0.54 |
| ▸ | MMP12 | P39900 | 1/20 | 0.54 |
| ▸ | MMP13 | P45452 | 1/20 | 0.54 |
| ▸ | MMP14 | P50281 | 1/20 | 0.54 |
| ▸ | REN | P00797 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7594281 | 0.93 | MMP1 (0.61) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7374244 | 0.91 | MME (0.57) | MMP1MMP2MMP9MMP7MMP12 | |
| SCHEMBL7595012 | 0.88 | MMP1 (0.66) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7404527 | 0.85 | MMP1 (0.65) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7385849 | 0.85 | MMP1 (0.65) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL6416810 | 0.85 | MMP1 (0.65) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7367573 | 0.84 | MMP1 (0.67) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7344017 | 0.84 | MME (0.55) | MMP1MMP2MMP9MMP7MMP12 | |
| SCHEMBL7428922 | 0.83 | MMP1 (0.63) | MMP1MMP2MMP3MMP8MMP9 | |
| SCHEMBL7382552 | 0.83 | MMP1 (0.63) | MMP1MMP2MMP3MMP8MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0826000-B1 | PEPTIDE COMPOUNDS WHICH INHIBIT METALLOPROTEINASE AND TNF LIBERATION AND THEIR THERAPEUTIC USES | DARWIN DISCOVERY LTD (GB) | 2002-10-23 | — | — | EP | disclosed |
| US-6110896-A | TRIPEPTIDYL DERIVATIVES HAVING A MERCAPTO OR ACYLTHIO GROUP AND WHICH ARE AMIDES; UTILITY AS MATRIX METALLOPROTEASE OR TNF INHIBITORS | DARWIN DISCOVERY, LTD. (GB) | 2000-08-29 | — | — | US | disclosed |