Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PAK4 | O96013 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5396490 | 1.00 | KMT2A (0.42) | KMT2AALOX15TSHRFLT1KDR | |
| SCHEMBL5410834 | 1.00 | KMT2A (0.42) | KMT2AALOX15TSHRFLT1KDR | |
| SCHEMBL5402361 | 0.79 | HRH4 (0.40) | KMT2AALOX15TSHRFLT1KDR | |
| SCHEMBL6401345 | 0.79 | LMNA (0.34) | KMT2AFLT1KDRLMNAPOLB | |
| SCHEMBL6401339 | 0.79 | LMNA (0.34) | KMT2AFLT1KDRLMNAPOLB | |
| SCHEMBL7114644 | 0.78 | KMT2A (0.36) | KMT2AALOX15TSHRFLT1KDR | |
| SCHEMBL7114640 | 0.78 | KMT2A (0.36) | KMT2AALOX15TSHRFLT1KDR | |
| SCHEMBL7126259 | 0.78 | POLB (0.33) | KMT2AHPGDALDH1A1POLBGAA | |
| SCHEMBL16466885 | 0.77 | HPGD (0.55) | KMT2AALOX15TSHRMEN1HPGD | |
| SCHEMBL4405167 | 0.76 | HRH4 (0.42) | KMT2AALOX15TSHRFLT1KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002096361-A2 | 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS | SUGEN, INC. (US) | 2002-12-05 | — | — | WO | disclosed |