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Sugi Predict / Compounds / SCHEMBL6401339

SCHEMBL6401339

SCHEMBL6401339

Cc1[nH]c(C=O)c(C)c1CCC(=O)N1C[C@@H](C)N[C@@H](C)C1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ LMNA P02545 3/20 0.34
▸ MAPT P10636 2/20 0.34
▸ TP53 P04637 2/20 0.33
▸ FGFR1 P11362 4/20 0.33
▸ KDR P35968 4/20 0.33
▸ PDGFRB P09619 3/20 0.33
▸ AURKA O14965 2/20 0.33
▸ RET P07949 2/20 0.33
▸ FLT1 P17948 2/20 0.33
▸ FLT3 P36888 2/20 0.33
▸ MAP4K2 Q12851 2/20 0.33
▸ STK3 Q13188 2/20 0.33
▸ AURKB Q96GD4 2/20 0.33
▸ GAK O14976 1/20 0.33
▸ RPS6KA5 O75582 1/20 0.33
▸ RPS6KA4 O75676 1/20 0.33
▸ LATS1 O95835 1/20 0.33
▸ CSNK2A2 P19784 1/20 0.33
▸ MAP2K2 P36507 1/20 0.33
▸ ZAP70 P43403 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6401345 1.00 LMNA (0.34) LMNAMAPTTP53FGFR1KDR
SCHEMBL7126259 0.87 POLB (0.33) POLBGAAKMT2A
SCHEMBL6220089 0.82 SPR (0.41) LMNAMAPTTP53SPR
SCHEMBL6321714 0.80 LMNA (0.41) LMNAMAPTTP53FGFR1KDR
SCHEMBL5410834 0.79 KMT2A (0.42) LMNAMAPTKDRFLT1POLB
SCHEMBL7589946 0.79 KMT2A (0.42) LMNAMAPTKDRFLT1POLB
SCHEMBL5396490 0.79 KMT2A (0.42) LMNAMAPTKDRFLT1POLB
SCHEMBL6220131 0.79 MEN1 (0.46) LMNAFLT3AURKBPOLBGAA
SCHEMBL6612923 0.76 SRC (0.39) FGFR1KDRPDGFRBLCKMLNR
SCHEMBL7117360 0.76 — —

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6861418-B2 4-aryl substituted indolinones SUGEN, INC. (US) 2005-03-01 — — US disclosed
US-20040157909-A1 4-Aryl substituted indolinones SUGEN, INC. 2004-08-12 — — US disclosed
US-6677368-B2 4-aryl substituted indolinones SUGEN, INC. 2004-01-13 — — US disclosed
EP-1349852-A2 4-(HETERO)ARYL SUBSTITUTED INDOLINONES Sugen, Inc. (US) 2003-10-08 — — EP disclosed
US-20030125370-A1 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS SUGEN, INC. 2003-07-03 — — US disclosed
US-20030069297-A1 4-aryl substituted indolinones SUGEN, INC. 2003-04-10 — — US disclosed
WO-2002096361-A2 5-ARALKYLSULFONYL-3- (PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS SUGEN, INC. (US) 2002-12-05 — — WO disclosed
WO-2002055517-A2 4-(HETERO)ARYL SUBSTITUTED INDOLINONES CUI JINGRONG (US) 2002-07-18 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030069297-A1 4-aryl substituted indolinones CDK5, CAMK4, TNK2 LMNA 3072/4885MAPT 2035/4885TP53 378/4885
US-20040157909-A1 4-Aryl substituted indolinones CDK5, CAMK4, TNK2 LMNA 3072/4885MAPT 2035/4885TP53 378/4885
US-20030125370-A1 5-ARALKYSUFONYL-3-(PYRROL-2-YLMETHYLIDENE)-2-INDOLINONE DERIVATIVES AS KINASE INHIBITORS DMPK, ADK, MAP3K20 LMNA 2232/4885MAPT 3167/4885TP53 1491/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.