Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TMEM97 | Q5BJF2 | 12/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.46 |
| ▸ | HRH1 | P35367 | 3/20 | 0.46 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.46 |
| ▸ | HRH2 | P25021 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.46 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | HTR1B | P28222 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
| ▸ | HTR1E | P28566 | 1/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.46 |
| ▸ | HTR2B | P41595 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7585007 | 0.88 | MAPT (0.51) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL7583688 | 0.82 | MAPT (0.42) | MAPTMAPK1HTTMEN1KMT2A | |
| SCHEMBL27301727 | 0.75 | CHRM4 (0.53) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL25889397 | 0.73 | TMEM97 (0.49) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL9727540 | 0.73 | NPSR1 (0.68) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL31703372 | 0.73 | TMEM97 (0.48) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL975238 | 0.72 | NPSR1 (0.60) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL7582764 | 0.72 | DRD2 (0.38) | MAPTMAPK1HTT | |
| SCHEMBL19212232 | 0.72 | TMEM97 (0.57) | TMEM97SIGMAR1HRH1HRH3HRH2 | |
| SCHEMBL31703435 | 0.71 | TMEM97 (0.49) | TMEM97SIGMAR1HRH1HRH3HRH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0675118-B1 | Biphenylderivatives, process for their preparation and their use as medicaments | EISAI CO LTD (JP) | 2002-10-09 | — | — | EP | disclosed |
| US-6281214-B1 | USEFUL FOR TREATING AND AMELIORATING MENTAL DISORDERS | EISAI CO., LTD (JP) | 2001-08-28 | — | — | US | disclosed |
| EP-0675118-A2 | Biphenylderivatives, process for their preparation and their use as medicaments | Eisai Co., Ltd. (JP) | 1995-10-04 | — | — | EP | disclosed |