Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.58 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.46 |
| ▸ | BRD4 | O60885 | 7/20 | 0.45 |
| ▸ | BRD2 | P25440 | 7/20 | 0.45 |
| ▸ | BRD3 | Q15059 | 7/20 | 0.45 |
| ▸ | CCKBR | P32239 | 5/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9261341 | 1.00 | SENP1 (0.58) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9261337 | 1.00 | SENP1 (0.58) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9251712 | 0.87 | SENP1 (0.58) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9251716 | 0.87 | SENP1 (0.58) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL5657926 | 0.86 | SENP1 (0.75) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9842497 | 0.83 | SENP1 (0.60) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9842511 | 0.83 | SENP1 (0.60) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9842505 | 0.83 | SENP1 (0.60) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9302105 | 0.82 | SENP1 (0.53) | SENP1SCN9ABRD4BRD2BRD3 | |
| SCHEMBL9301274 | 0.82 | SENP1 (0.53) | SENP1SCN9ABRD4BRD2BRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002099388-A2 | BENZODIAZEPINE BRADYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 2002-12-12 | — | — | WO | claimed |
| WO-2002099388-A2 | BENZODIAZEPINE BRADYKININ ANTAGONISTS | MERCK & CO., INC. (US) | 2002-12-12 | — | — | WO | disclosed |
| US-5451582-A | Cholecystokinins and gastrin receptor antagonists | MERCK SHARP & DOHME LTD. (GB) | 1995-09-19 | — | — | US | disclosed |