Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC29A1 | Q99808 | 4/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.54 |
| ▸ | SLC22A6 | Q4U2R8 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.48 |
| ▸ | POLA1 | P09884 | 1/20 | 0.44 |
| ▸ | POLG | P54098 | 1/20 | 0.44 |
| ▸ | HPRT1 | P00492 | 3/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.41 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.41 |
| ▸ | CDK2 | P24941 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12149448 | 0.84 | SLC29A1 (0.51) | SLC29A1CYP2C19FGFR1SLC22A6POLB | |
| SCHEMBL7591540 | 0.84 | SLC29A1 (0.63) | SLC29A1CYP2C19POLBCYP1A2CYP3A4 | |
| SCHEMBL1565558 | 0.82 | FGFR1 (0.57) | CYP2C19FGFR1SLC22A6POLBPOLA1 | |
| SCHEMBL7128447 | 0.82 | FGFR1 (0.48) | SLC29A1CYP2C19FGFR1SLC22A6POLB | |
| SCHEMBL7119964 | 0.82 | FGFR1 (0.48) | SLC29A1CYP2C19FGFR1SLC22A6POLB | |
| SCHEMBL2607253 | 0.82 | SLC22A6 (0.62) | CYP2C19FGFR1SLC22A6POLBPOLA1 | |
| Pmedap SCHEMBL29571667 | 0.81 | FGFR1 (0.72) | FGFR1SLC22A6POLBCYP3A4POLA1 | |
| Pmedap SCHEMBL215611 | 0.81 | FGFR1 (0.72) | FGFR1SLC22A6POLBCYP3A4POLA1 | |
| SCHEMBL1565553 | 0.81 | FGFR1 (0.56) | CYP2C19FGFR1SLC22A6POLBPOLA1 | |
| SCHEMBL1567264 | 0.81 | FGFR1 (0.58) | CYP2C19FGFR1SLC22A6POLBPOLA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139604-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-9139604-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2015-09-22 | — | — | US | disclosed |
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2015-01-22 | — | — | US | disclosed |
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2015-01-22 | — | — | US | disclosed |
| US-8871785-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-8871785-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2014-10-28 | — | — | US | disclosed |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. (US) | 2011-11-24 | — | — | US | disclosed |
| US-8022083-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-8022083-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2011-09-20 | — | — | US | disclosed |
| US-20110071101-A1 | Nucleoside Phosphonate Analogs | BOOJAMRA CONSTANTINE G | 2011-03-24 | — | — | US | disclosed |
| US-20090275535-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2009-11-05 | — | — | US | disclosed |
| US-20090275535-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | GILEAD SCIENCES, INC. | 2009-11-05 | — | — | US | disclosed |
| US-7429565-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429565-B2 | Antiviral phosphonate analogs | GILEAD SCIENCES, INC. (US) | 2008-09-30 | — | — | US | disclosed |
| EP-0919562-B1 | PHOSPHONATE NUCLEOTIDE COMPOUNDS | MITSUBISHI CHEM CORP (JP) | 2002-11-06 | — | — | EP | disclosed |
| US-6194398-B1 | VIRICIDES AGAINST HUMAN IMMUNODEFICIENCY VIRUS, HERPES SIMPLEX VIRUS, HEPATITIS B VIRUS; ANTITUMOR AGENTS; SIDE EFFECT REDUCTION; ORAL ABSORPTION BIOAVAILABILITY; A 2-AMINO-6-HYDROCARBYLTHIO-9-(2-(PHOSPHONOMETHOXY)ETHYL-9H-PURINE | MITSUBISHI CHEMICAL CORPORATION (JP) | 2001-02-27 | — | — | US | disclosed |
| EP-0919562-A1 | PHOSPHONATE NUCLEOTIDE COMPOUNDS | MITSUBISHI CHEMICAL CORPORATION (JP) | 1999-06-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150025039-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | SLC29A1 113/4885CYP2C19 4055/4885FGFR1 3513/4885 |
| US-20110071101-A1 | Nucleoside Phosphonate Analogs | TYMP, PNP, NUDT1 | SLC29A1 8/4885CYP2C19 2247/4885FGFR1 2035/4885 |
| US-20110288053-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | SLC29A1 113/4885CYP2C19 4055/4885FGFR1 3513/4885 |
| US-20090275535-A1 | ANTIVIRAL PHOSPHONATE ANALOGS | TYMP, ITPA, PNP | SLC29A1 113/4885CYP2C19 4055/4885FGFR1 3513/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.