Pmedap

Pmedap

SCHEMBL215611

Nc1nc(N)c2ncn(CCOCP(=O)(O)O)c2n1

nearest known ligand 0.72

Full drug profile on Sugi Atlas →

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
FGFR1 P11362 3/20 0.72
SLC22A6 Q4U2R8 2/20 0.72
POLB P06746 4/20 0.55
CDK1 P06493 1/20 0.51
CCNB1 P14635 1/20 0.51
CCNE1 P24864 1/20 0.51
CDK2 P24941 1/20 0.51
POLA1 P09884 2/20 0.51
POLG P54098 2/20 0.51
ABCB11 O95342 1/20 0.46
FAP Q12884 1/20 0.46
HPRT1 P00492 4/20 0.46
ENPP1 P22413 1/20 0.45
PNP P00491 1/20 0.44
CYP3A4 P08684 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Pmedap SCHEMBL29571667 1.00 FGFR1 (0.72) FGFR1SLC22A6POLBCDK1CCNB1
SCHEMBL2734810 0.90 FGFR1 (0.59) FGFR1SLC22A6POLBCDK1CCNB1
SCHEMBL1566036 0.89 FGFR1 (0.63) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL30759944 0.89 FGFR1 (0.63) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL23015054 0.88 SLC22A6 (0.62) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL2607253 0.88 SLC22A6 (0.62) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL29626981 0.88 SLC22A6 (0.62) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL24721834 0.87 FGFR1 (0.56) FGFR1SLC22A6POLBCDK1CCNB1
SCHEMBL1567494 0.86 FGFR1 (0.60) FGFR1SLC22A6POLBPOLA1POLG
SCHEMBL30824623 0.86 FGFR1 (0.60) FGFR1SLC22A6POLBPOLA1POLG

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 220 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12497435-B2 Multimerization of IL-15/IL-15R-alpha-fc complexes to enhance immunotherapy MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2025-12-16 US claimed
US-20230110614-A1 HEPARIN AND N-ACETYLCYSTEINE FOR THE TREATMENT OF A RESPIRATORY VIRUS ATOSSA THERAPEUTICS, INC. 2023-04-13 US claimed
EP-4125936-A1 HEPARIN AND N-ACETYLCYSTEINE FOR THE TREATMENT OF A RESPIRATORY VIRUS Atossa Therapeutics, Inc. (US) 2023-02-08 EP claimed
US-20220106375-A1 MULTIMERIZATION OF IL-15/IL-15R-ALPHA-FC COMPLEXES TO ENHANCE IMMUNOTHERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2022-04-07 US claimed
EP-3908314-A1 MULTIMERIZATION OF IL-15/IL-15R-ALPHA-FC COMPLEXES TO ENHANCE IMMUNOTHERAPY Memorial Sloan Kettering Cancer Center (US) 2021-11-17 EP claimed
WO-2021194890-A1 HEPARIN AND N-ACETYLCYSTEINE FOR THE TREATMENT OF A RESPIRATORY VIRUS ATOSSA THERAPEUTICS, INC. (US) 2021-09-30 WO claimed
WO-2020146835-A1 MULTIMERIZATION OF IL-15/IL-15R-ALPHA-FC COMPLEXES TO ENHANCE IMMUNOTHERAPY MEMORIAL SLOAN KETTERING CANCER CENTER (US) 2020-07-16 WO claimed
US-8580753-B2 Modulation of telomere length in telomerase positive cells and cancer therapy ALT SOLUTIONS INC. (US) 2013-11-12 US claimed
EP-2223927-A2 Cyclic phosphonic acid based prodrugs of PMEA and its analogues Metabasis Therapeutics, Inc. (US) 2010-09-01 EP claimed
EP-1532157-A4 NOVEL PHOSPHONIC ACID BASED PRODRUGS OF PMEA AND ITS ANALOGUES METABASIS THERAPEUTICS INC (US) 2009-02-25 EP claimed
US-7205404-B1 Phosphorus-containing prodrugs METABASIS THERAPEUTICS, INC. (US) 2007-04-17 US claimed
EP-1165570-B9 NOVEL PHOSPHORUS-CONTAINING PRODRUGS METABASIS THERAPEUTICS INC (US) 2007-02-21 EP claimed
EP-1165570-B1 NOVEL PHOSPHORUS-CONTAINING PRODRUGS METABASIS THERAPEUTICS INC (US) 2006-08-23 EP claimed
WO-2005090370-A1 PHARMACOLOGICALLY ACTIVE AGENTS CONTAINING ESTERIFIED PHOSPHONATES AND METHODS FOR USE THEREOF THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) 2005-09-29 WO claimed
US-20050192246-A1 Pharmacologically active agents containing esterified phosphonates and methods for use thereof US ARMY, SECRETARY OF THE ARMY 2005-09-01 US claimed
EP-1532157-A2 NOVEL PHOSPHONIC ACID BASED PRODRUGS OF PMEA AND ITS ANALOGUES Metabasis Therapeutics, Inc. (US) 2005-05-25 EP claimed
WO-2004037161-A2 CYCLIC PRODRUGS OF PMEA ONE OF ITS ANALOGUES METABASIS THERAPEUTICS, INC. (US) 2004-05-06 WO claimed
US-20030229225-A1 Novel phosphonic acid based prodrugs of PMEA and its analogues METABASIS THERAPEUTICS, INC. 2003-12-11 US claimed
US-12576103-B2 Heparin and N-acetylcysteine for the treatment of lung injury ATOSSA THERAPEUTICS, INC. (US) 2026-03-17 US disclosed
EP-0350287-A2 Lipid derivatives of antiviral nucleosides, liposomal incorporation and method of use NeXstar Pharmaceuticals, Inc. (US) 1990-01-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030229225-A1 Novel phosphonic acid based prodrugs of PMEA and its analogues MTAP, PNP, MPO FGFR1 3580/4885SLC22A6 432/4885POLB 84/4885
US-20050192246-A1 Pharmacologically active agents containing esterified phosphonates and methods for use thereof PHPT1, PPIP5K2, PHOSPHO1 FGFR1 592/4885SLC22A6 2751/4885POLB 621/4885
US-12576103-B2 Heparin and N-acetylcysteine for the treatment of lung injury SERPINC1, TXNRD2, TXN FGFR1 2330/4885SLC22A6 1497/4885POLB 2995/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.