Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GNRHR | P30968 | 16/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | EDNRB | P24530 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7595053 | 0.94 | GNRHR (0.35) | GNRHRKMT2AEDNRBMEN1KCNH2 | |
| SCHEMBL7592371 | 0.92 | GNRHR (0.35) | GNRHRKMT2AEDNRB | |
| SCHEMBL7598726 | 0.92 | L3MBTL1 (0.37) | GNRHRKMT2AEDNRBMEN1 | |
| SCHEMBL804312 | 0.92 | GNRHR (0.36) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL7594784 | 0.92 | GNRHR (0.35) | GNRHRKMT2AEDNRBMEN1KCNH2 | |
| SCHEMBL8186567 | 0.89 | GNRHR (0.35) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL7593455 | 0.87 | GNRHR (0.36) | GNRHRKMT2AEDNRBMEN1KCNH2 | |
| SCHEMBL6704311 | 0.86 | GNRHR (0.36) | GNRHRKMT2AEDNRBKCNH2 | |
| SCHEMBL7854155 | 0.86 | ADORA2B (0.42) | GNRHRKMT2AEDNRBMEN1 | |
| SCHEMBL7591544 | 0.85 | GNRHR (0.43) | GNRHRKMT2AEDNRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0846119-B1 | THIENOPYRIMIDINE DERIVATIVES, THEIR PRODUCTION AND USE AS ENDOTHELIN ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 2002-11-13 | — | — | EP | disclosed |
| US-6140325-A | HAS ENDOTHELIN ANTAGONISTIC ACTION; FOR TREATING LIVER HYPOFUNCTION, ACUTE RENAL INSUFFICIENCY, CARDIAC INFARCTION OR LIVER INSUFFICIENCY, VASOCONSTRICTION | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2000-10-31 | — | — | US | disclosed |