Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.52 |
| ▸ | PPARG | P37231 | 10/20 | 0.42 |
| ▸ | PPARA | Q07869 | 9/20 | 0.42 |
| ▸ | PPARD | Q03181 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.39 |
| ▸ | HPGDS | O60760 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11123121 | 0.78 | ALOX15 (0.43) | CYP1A2HPGDSSMN1; SMN2 | |
| SCHEMBL12304043 | 0.77 | ALOX15 (0.39) | NR4A2ADORA2AADORA1SMN1; SMN2 | |
| SCHEMBL19502669 | 0.75 | CYP1A2 (0.57) | NR4A2PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL5376863 | 0.74 | NR4A2 (0.39) | NR4A2ADORA2AADORA1HPGDSSMN1; SMN2 | |
| SCHEMBL7588663 | 0.74 | PPARG (0.37) | NR4A2PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL5381820 | 0.73 | LMNA (0.54) | HPGDSSMN1; SMN2 | |
| SCHEMBL1582615 | 0.73 | KMT2A (0.67) | NR4A2PPARGPPARAPPARDCYP1A2 | |
| SCHEMBL11624564 | 0.72 | ALOX15 (0.41) | ADORA2AADORA1HPGDSSMN1; SMN2 | |
| SCHEMBL27794351 | 0.70 | NR4A2 (0.32) | NR4A2SMN1; SMN2 | |
| SCHEMBL28986044 | 0.69 | TAOK1 (0.48) | PPARGPPARAPPARDEPHX2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1228067-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGYLCEMIC AND HYPOLIPIDEMIC ACTIVITY | Takeda Chemical Industries, Ltd. (JP) | 2002-08-07 | — | — | EP | disclosed |
| WO-2001038325-A1 | 5-MEMBERED N-HETEROCYCLIC COMPOUNDS WITH HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITY | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 2001-05-31 | — | — | WO | disclosed |