Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5509464 | 0.75 | MEN1 (0.40) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL11181041 | 0.75 | MEN1 (0.37) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL10853904 | 0.70 | MEN1 (0.44) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL31380893 | 0.69 | MEN1 (0.43) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL8415307 | 0.67 | MEN1 (0.42) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL28346195 | 0.66 | MAPT (0.41) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL16322074 | 0.65 | MAPT (0.40) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| SCHEMBL7646733 | 0.65 | MAPT (0.40) | MAPTMEN1KMT2ARAB9AL3MBTL1 | |
| Methoxymethane SCHEMBL27770060 | 0.64 | MAPT (0.52) | MAPTMEN1KMT2ARAB9AALDH1A1 | |
| SCHEMBL1426467 | 0.63 | MEN1 (0.39) | MAPTMEN1KMT2ARAB9AL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6448256-B1 | PRECURSORS OF N-SUBSTITUTED DERIVATIVES OF 6-AMINOURACILS, 6-AMINOISOCYTOSINES, GUANINES AND 2-AMINOADENINES HAVING A CLEAVABLE ESTER GROUP; GREATER WATER SOLUBILITY AND ORAL BIOAVAILABILITY; TREATING GRAM POSITIVE BACTERIAL INFECTIONS | UNIVERSITY OF MASSACHUSETTS | 2002-09-10 | — | — | US | disclosed |
| EP-1185517-A1 | ANTIBIOTIC PRODRUGS | University of Massachusetts (US) | 2002-03-13 | — | — | EP | disclosed |
| WO-2000071523-A1 | ANTIBIOTIC PRODRUGS | UNIVERSITY OF MASSACHUSETTS (US) | 2000-11-30 | — | — | WO | disclosed |