Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 3/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | SLC6A9 | P48067 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3644854 | 0.89 | CHRM3 (0.51) | CHRM3SLC6A9 | |
| SCHEMBL8202170 | 0.87 | — | — | |
| SCHEMBL21033594 | 0.87 | — | — | |
| SCHEMBL6819282 | 0.82 | CHRNB4 (0.50) | CHRM3SLC6A9 | |
| SCHEMBL1797593 | 0.82 | CHRNB4 (0.50) | CHRM3SLC6A9 | |
| SCHEMBL1797592 | 0.82 | CHRNB4 (0.50) | CHRM3SLC6A9 | |
| SCHEMBL20412693 | 0.81 | CHRM3 (0.71) | CHRM3 | |
| SCHEMBL13403259 | 0.81 | CHRNB4 (0.49) | CHRM3SLC6A9 | |
| SCHEMBL14470862 | 0.81 | KDM4E (0.48) | CHRM3KDM4E | |
| SCHEMBL220309 | 0.80 | KDM4E (0.45) | CHRM3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0881216-B1 | Transdermal patch comprising solid methylphenidate | JOHNSON MATTHEY PLC (GB) | 2002-11-06 | — | — | EP | claimed |
| US-8283472-B2 | Synthesis of methylphenidate and analogs thereof | MALLINCKRODT LLC (US) | 2012-10-09 | — | — | US | disclosed |
| US-20100179327-A1 | Synthesis of Methylphenidate and Analogs Thereof | MALLINCKRODT INC. (US) | 2010-07-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100179327-A1 | Synthesis of Methylphenidate and Analogs Thereof | COMT, PNMT, BCAT2 | CHRM3 410/4885KDM4E 173/4885SLC6A9 669/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.