Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 5/20 | 0.77 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.77 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.74 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.74 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.74 |
| ▸ | HPGD | P15428 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.59 |
| ▸ | GAA | P10253 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.59 |
| ▸ | PKM | P14618 | 1/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | CASP1 | P29466 | 1/20 | 0.59 |
| ▸ | HTT | P42858 | 1/20 | 0.59 |
| ▸ | CASP7 | P55210 | 1/20 | 0.59 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.57 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877025 | 0.85 | HPGD (1.00) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL6982894 | 0.85 | HPGD (1.00) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19291210 | 0.85 | HPGD (0.80) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7648334 | 0.83 | KDM4E (0.72) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7655012 | 0.83 | KDM4E (0.72) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7649819 | 0.83 | KDM4E (0.72) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL7745468 | 0.82 | LMNA (0.70) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17242598 | 0.82 | KDM4E (0.70) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL19577097 | 0.81 | HSD17B10 (0.62) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL17242517 | 0.81 | KDM4E (0.76) | MEN1KMT2AALDH1A1KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1207886-B1 | SPHINGOMYELINASE INHIBITORS AS AGENTS WITH ANTIAPOPTOTIC AND ANTISEPTIC ACTION | BIOFRONTERA PHARMACEUTICALS GM (DE) | 2005-11-16 | — | — | EP | disclosed |
| US-6407116-B1 | 2,4-DIOXO-1,2,3,4-TETRAHYDROQUINAZOLINE DERIVATIVES; ANTIALLERGENS, ANTIASTHMATICS, ANTIHISTAMINES, AND ANTIINFLAMMATORY AGENTS | TAKEDA CHEMICAL INDUSTRIES, INC. (JP) | 2002-06-18 | — | — | US | disclosed |
| EP-1207886-A2 | SPHINGOMYELINASE INHIBITORS AS AGENTS WITH ANTIAPOPTOTIC AND ANTISEPTIC ACTION | Biofrontera Pharmaceuticals GmbH (DE) | 2002-05-29 | — | — | EP | disclosed |
| WO-2000072833-A2 | PHARMACEUTICAL PREPARATIONS FOR INHIBITING SPHINGOMYELINASE | Universität Heidelberg (DE) | 2000-12-07 | — | — | WO | disclosed |
| EP-1026160-A1 | NITROGENOUS FUSED-RING COMPOUNDS, PROCESS FOR THE PREPARATION OF THE SAME, AND DRUGS | Takeda Chemical Industries, Ltd. (JP) | 2000-08-09 | — | — | EP | disclosed |