Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 1.00 |
| ▸ | MEN1 | O00255 | 3/20 | 0.74 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.74 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.68 |
| ▸ | TSHR | P16473 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.60 |
| ▸ | USP2 | O75604 | 1/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | ACHE | P22303 | 1/20 | 0.60 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.60 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30877025 | 1.00 | HPGD (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL19291210 | 0.89 | HPGD (0.80) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL1067505 | 0.89 | HPGD (0.78) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL10487828 | 0.85 | HPGD (0.74) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7593290 | 0.85 | MEN1 (0.77) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6295507 | 0.85 | MEN1 (1.00) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL7101724 | 0.85 | KMT2A (0.78) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6980977 | 0.84 | PKM (0.79) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL6976707 | 0.83 | SMN1; SMN2 (0.76) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 | |
| SCHEMBL12821913 | 0.83 | HPGD (0.70) | HPGDALDH1A1KDM4ESMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024091450-A1 | COMPOUNDS AND METHODS FOR TREATING CANCER | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2024-05-02 | — | — | WO | disclosed |
| US-20210220331-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | THE UNITED STATES GOVERNMENT REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS | 2021-07-22 | — | — | US | disclosed |
| EP-3452447-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | The Regents of The University of California (US) | 2019-03-13 | — | — | EP | disclosed |
| WO-2017192665-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2017-11-09 | — | — | WO | disclosed |
| US-20030199530-A1 | New compounds derived from quinazoline | LES LABORATORIES SERVIER (FR) | 2003-10-23 | — | — | US | disclosed |
| EP-1346992-A1 | Quinazoline derivatives, process for their preparation and pharmaceutical compositions containing them | Les Laboratoires Servier (FR) | 2003-09-24 | — | — | EP | disclosed |
| US-5710319-A | Process for the preparation of substituted quinazoline-2,4-diones | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-01-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030199530-A1 | New compounds derived from quinazoline | NQO2, XDH, DRD1 | HPGD 1378/4885ALDH1A1 331/4885KDM4E 4217/4885 |
| US-20210220331-A1 | INHIBITORS OF IRES-MEDIATED PROTEIN SYNTHESIS | EIF4EBP1, EIF4E, EIF2A | HPGD 3898/4885ALDH1A1 4611/4885KDM4E 1896/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.