Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.62 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.62 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.62 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.62 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.62 |
| ▸ | DRD1 | P21728 | 1/20 | 0.62 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18938268 | 0.80 | TDP1 (0.64) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| SCHEMBL22486487 | 0.78 | TDP1 (0.78) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| Timolol SCHEMBL1587691 | 0.77 | CYP1A2 (1.00) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| SCHEMBL9817959 | 0.77 | CYP1A2 (0.63) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| Timolol SCHEMBL222970 | 0.77 | CYP1A2 (1.00) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| Timolol SCHEMBL4912 | 0.77 | CYP1A2 (1.00) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| Timolol SCHEMBL2553603 | 0.77 | CYP1A2 (1.00) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| SCHEMBL11529594 | 0.77 | HTT (0.61) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| Timolol SCHEMBL7591293 | 0.76 | CYP1A2 (0.98) | TDP1CYP1A2ADRB2ADRB1CYP3A4 | |
| SCHEMBL15608432 | 0.76 | CYP1A2 (0.74) | TDP1CYP1A2ADRB2ADRB1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964224-B1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | POLYACTIVA PTY LTD (AU) | 2024-07-03 | — | — | EP | disclosed |
| US-11787906-B2 | Biodegradable drug-polymer conjugate | POLYACTIVA PTY LTD (AU) | 2023-10-17 | — | — | US | disclosed |
| US-20200123322-A1 | BIODEGRADABLE DRUG-POLYMER CONJUGATE | POLYACTIVA PTY LTD (AU) | 2020-04-23 | — | — | US | disclosed |
| CN-110662561-A | Biodegradable drug-polymer conjugates | 波利艾克蒂瓦有限公司 | 2020-01-07 | — | — | CN | disclosed |
| US-10111886-B2 | Polymer conjugate for delivery of a bioactive agent | POLYACTIVA PTY LTD (AU) | 2018-10-30 | — | — | US | disclosed |
| US-10113033-B2 | Polymer conjugate for delivery of a bioactive agent | POLYACTIVA PTY LTD (AU) | 2018-10-30 | — | — | US | disclosed |
| WO-2018140580-A1 | NANOPARTICLES FOR SUSTAINED OPHTHALMIC DRUG DELIVERY AND METHODS OF USE | 2C TECH CORP. (US) | 2018-08-02 | — | — | WO | disclosed |
| US-20170216308-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | POLYACTIVA PTY LTD (AU) | 2017-08-03 | — | — | US | disclosed |
| US-20170182173-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | POLYACTIVA PTY LTD (AU) | 2017-06-29 | — | — | US | disclosed |
| US-9572892-B2 | Polymer conjugate for delivery of a bioactive agent | POLYACTIVA PTY LTD (AU) | 2017-02-21 | — | — | US | disclosed |
| US-20160000929-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | POLYACTIVA PTY LTD (AU) | 2016-01-07 | — | — | US | disclosed |
| EP-0941218-B1 | ANTITHROMBOTIC ORGANIC NITRATES | NICOX SA (FR) | 2002-10-16 | — | — | EP | disclosed |
| US-6242432-B1 | ANTIHYPERTENSIVE ACTIVITY, ANTIHYPERSENSITIVE ACTIVITY; TREATMENT OF CARDIOVASCULAR DISEASE | NICOX S.A. (FR) | 2001-06-05 | — | — | US | disclosed |
| WO-1990007927-A1 | AGENT FOR TREATING PROSTATIC HYPERPLASIA | SEINFELD HUGO (DE) | 1990-07-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200123322-A1 | BIODEGRADABLE DRUG-POLYMER CONJUGATE | ADRB3, PTGER3, CHRNE | TDP1 3114/4885CYP1A2 101/4885ADRB2 13/4885 |
| US-10113033-B2 | Polymer conjugate for delivery of a bioactive agent | PTGIS, PTGIR, PGF | TDP1 1112/4885CYP1A2 1386/4885ADRB2 2436/4885 |
| US-10111886-B2 | Polymer conjugate for delivery of a bioactive agent | PTGIS, PTGIR, PGF | TDP1 1152/4885CYP1A2 1463/4885ADRB2 74/4885 |
| US-20160000929-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | PTGIS, PTGIR, PGF | TDP1 1495/4885CYP1A2 1282/4885ADRB2 101/4885 |
| US-20170216308-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | PTGIS, PTGIR, PGF | TDP1 1152/4885CYP1A2 1463/4885ADRB2 74/4885 |
| US-20170182173-A1 | POLYMER CONJUGATE FOR DELIVERY OF A BIOACTIVE AGENT | PTGIS, PTGIR, PGF | TDP1 1112/4885CYP1A2 1386/4885ADRB2 2436/4885 |
| US-11787906-B2 | Biodegradable drug-polymer conjugate | ADRB3, PTGER3, CHRM3 | TDP1 2961/4885CYP1A2 94/4885ADRB2 16/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.