SCHEMBL7594572

SCHEMBL7594572

C1=C[SiH2]C=C1.O=C(Oc1ccc2ccccc2c1)c1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 8/20 0.79
MEN1 O00255 3/20 0.79
MAPT P10636 3/20 0.79
TDP1 Q9NUW8 2/20 0.79
CA12 O43570 2/20 0.55
CA9 Q16790 2/20 0.55
POLB P06746 1/20 0.52
PDGFRB P09619 2/20 0.51
PDGFRA P16234 2/20 0.51
ALDH1A1 P00352 2/20 0.50
HSD17B10 Q99714 2/20 0.50
PARP10 Q53GL7 1/20 0.47
ESR1 P03372 1/20 0.47
MMP1 P03956 2/20 0.47
MMP12 P39900 1/20 0.47
CASP3 P42574 1/20 0.46
SENP8 Q96LD8 1/20 0.46
SENP7 Q9BQF6 1/20 0.46
SENP6 Q9GZR1 1/20 0.46
MMP2 P08253 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1639878 0.89 KMT2A (1.00) KMT2AMEN1MAPTTDP1CA12
SCHEMBL30523105 0.89 KMT2A (1.00) KMT2AMEN1MAPTTDP1CA12
Ammonia Solution, Strong SCHEMBL11705203 0.87 KMT2A (0.96) KMT2AMEN1MAPTTDP1CA12
SCHEMBL18058690 0.85 KMT2A (0.93) KMT2AMEN1MAPTTDP1CA12
Benzoic Acid SCHEMBL9956914 0.84 KMT2A (0.90) KMT2AMEN1MAPTTDP1CA12
SCHEMBL16236876 0.81 KMT2A (0.84) KMT2AMEN1MAPTTDP1CA12
SCHEMBL16236336 0.81 KMT2A (0.84) KMT2AMEN1MAPTTDP1CA12
Betanaphthol SCHEMBL16236859 0.81 KMT2A (0.84) KMT2AMEN1MAPTTDP1CA12
SCHEMBL27267181 0.80 KMT2A (0.83) KMT2AMEN1MAPTTDP1CA12
SCHEMBL3911876 0.78 KMT2A (0.78) KMT2AMEN1MAPTTDP1CA12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0768867-B1 DOSAGE FORM FOR ADMINISTERING DRUG IN LIQUID FORMULATION ALZA CORP (US) 2002-10-09 EP disclosed
EP-0768867-A1 DOSAGE FORM FOR ADMINISTERING DRUG IN LIQUID FORMULATION ALZA CORPORATION (US) 1997-04-23 EP disclosed
WO-1995034285-A1 DOSAGE FORM FOR ADMINISTERING DRUG IN LIQUID FORMULATION ALZA CORPORATION (US) 1995-12-21 WO disclosed
EP-0313992-B1 Plurality of tiny pills in liquid dosage form ALZA CORP (US) 1994-06-22 EP disclosed
US-5030454-A Method for delivering drug in tiny pills in liquid carrier ALZA CORPORATION (US) 1991-07-09 US disclosed
US-4961932-A Plurality of tiny pills in liquid dosage form ALZA CORPORATION (US) 1990-10-09 US disclosed
US-4853229-A Method for adminstering tiny pills ALZA CORPORATION (US) 1989-08-01 US disclosed
EP-0313992-A1 Plurality of tiny pills in liquid dosage form ALZA CORPORATION (US) 1989-05-03 EP disclosed