Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 2/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | MMP2 | P08253 | 7/20 | 0.39 |
| ▸ | MMP13 | P45452 | 6/20 | 0.39 |
| ▸ | MMP1 | P03956 | 5/20 | 0.39 |
| ▸ | MMP9 | P14780 | 5/20 | 0.39 |
| ▸ | MMP12 | P39900 | 4/20 | 0.39 |
| ▸ | MMP14 | P50281 | 4/20 | 0.39 |
| ▸ | MMP3 | P08254 | 3/20 | 0.39 |
| ▸ | CFD | P00746 | 1/20 | 0.38 |
| ▸ | PLG | P00747 | 1/20 | 0.38 |
| ▸ | PLAU | P00749 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.38 |
| ▸ | F7 | P08709 | 1/20 | 0.38 |
| ▸ | TPSB2 | P20231 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 4/20 | 0.38 |
| ▸ | CA2 | P00918 | 4/20 | 0.38 |
| ▸ | MMP8 | P22894 | 4/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2895999 | 0.75 | CA2 (0.41) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL6479936 | 0.74 | CA2 (0.45) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL31299569 | 0.74 | CA1 (0.38) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL9562242 | 0.74 | CA1 (0.38) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL6474903 | 0.73 | PIK3CD (0.39) | CA1CA2L3MBTL1 | |
| SCHEMBL3696269 | 0.73 | CA2 (0.42) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL11103498 | 0.73 | CXCL8 (0.53) | CXCL8CHRM1AKR1B1MMP2MMP13 | |
| SCHEMBL6900759 | 0.73 | CA2 (0.46) | MMP2MMP13MMP1MMP9CA1 | |
| Iodide SCHEMBL5315919 | 0.73 | PIK3CD (0.44) | MMP2MMP13MMP1MMP9CA1 | |
| SCHEMBL27366575 | 0.73 | PIK3CD (0.44) | MMP2MMP13MMP1MMP9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255726-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8 INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.P.A. (IT) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001058852-A2 | (R)-2-ARYL-PROPIONAMIDES, USEFUL IN THE INHIBITION OF IL-8-INDUCED CHEMIOTAXIS OF NEUTROPHILS | Dompé S.p.A. (IT) | 2001-08-16 | — | — | WO | disclosed |