SCHEMBL7595489

SCHEMBL7595489

O=C(CO)Nc1c(I)c(CC(O)CO)c(I)c(NC(=O)CO)c1I

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.34
SMN1; SMN2 Q16637 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8377087 0.86 LMNA (0.32) LMNASMN1; SMN2
SCHEMBL28584676 0.83 LMNA (0.33) LMNASMN1; SMN2
SCHEMBL7589733 0.82 LMNA (0.38) LMNASMN1; SMN2
SCHEMBL7591808 0.82 CYP2C19 (0.38) LMNA
SCHEMBL7590517 0.82 LMNA (0.32) LMNA
SCHEMBL9356491 0.79 LMNA (0.38) LMNA
SCHEMBL7594166 0.78 LMNA (0.33) LMNA
SCHEMBL7592516 0.76 LMNA (0.35) LMNASMN1; SMN2
SCHEMBL9352719 0.76 LMNA (0.34) LMNA
SCHEMBL10624509 0.75 LMNA (0.57) LMNASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6448442-B1 X-RAY CONTRAST AGENTS; LOW VISCOSITY IODINATED ARYL COMPOUNDS AMERSHAM HEALTH AS (NO) 2002-09-10 US disclosed
US-6310243-B1 BENZENE COMPOUNDS IN WHICH 3 NON-ADJACENT RING ATOMS ARE SUBSTITUTED WITH IODINE, 2 OF THE REMAINING RING ATOMS ARE AMIDE SUBSTITUTED WITH HYDROXY AND THE OTHER REMAINING RING ATOM IS A NON-AMIDE, HYDROXY-SUBSTITUTED NONIONIC MOIETY NYCOMED IMAGING AS (NO) 2001-10-30 US disclosed