Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.52 |
| ▸ | NT5E | P21589 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.49 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.49 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5963793 | 0.92 | ADORA3 (0.58) | ADORA3NT5ELMNAHIF1AADORA2A | |
| SCHEMBL7994255 | 0.92 | ADORA3 (0.58) | ADORA3NT5ELMNAHIF1AADORA2A | |
| SCHEMBL5963261 | 0.85 | ADORA2A (0.61) | ADORA3NT5ELMNAHIF1AADORA2A | |
| SCHEMBL29759464 | 0.80 | LMNA (0.59) | ADORA3NT5ELMNAHIF1AADORA2A | |
| SCHEMBL1058338 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 | |
| SCHEMBL2255481 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 | |
| SCHEMBL29705797 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 | |
| SCHEMBL2255484 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 | |
| SCHEMBL8495134 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 | |
| SCHEMBL1058335 | 0.79 | ADORA3 (0.68) | ADORA3HIF1AADORA2AADORA2BSLC29A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1223173-A2 | Novel 2'-O-alkyl nucleosides and phosphoramidites processes for the preparation and uses thereof | ISIS PHARMACEUTICALS, INC. (US) | 2002-07-17 | — | — | EP | disclosed |
| US-5914396-A | 2'-O-modified nucleosides and phosphoramidites | ISIS PHARMACEUTICALS, INC. (US) | 1999-06-22 | — | — | US | disclosed |
| US-5506351-A | Process for the preparation of 2'-O-alkyl guanosine and related compounds | ISIS PHARMACEUTICALS (US) | 1996-04-09 | — | — | US | disclosed |