Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 8/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.46 |
| ▸ | DRD2 | P14416 | 5/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | HTR3A | P46098 | 5/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7601003 | 0.97 | HTR1A (0.51) | HTR1ADRD3DRD2HTR2AHTR3A | |
| SCHEMBL7600196 | 0.92 | DRD3 (0.44) | HTR1ADRD3DRD2HTR2AHTR3A | |
| SCHEMBL7599590 | 0.91 | HTR1A (0.39) | HTR1ADRD3DRD2HTR2AHTR3A | |
| SCHEMBL7608065 | 0.91 | HTR1A (0.49) | HTR1ADRD3DRD2HTR2AHTR3A | |
| SCHEMBL7596831 | 0.88 | HTR1A (0.42) | HTR1ADRD3DRD2HTR2ASLC6A4 | |
| SCHEMBL7596536 | 0.88 | DRD3 (0.45) | HTR1ADRD3DRD2HTR3A | |
| SCHEMBL7600344 | 0.88 | HTR3A (0.42) | HTR1ADRD3DRD2HTR2AHTR3A | |
| SCHEMBL7599958 | 0.88 | DRD3 (0.43) | HTR1ADRD3DRD2HTR7 | |
| SCHEMBL7600219 | 0.88 | HTR1A (0.41) | HTR1ADRD3DRD2HTR3ASLC6A4 | |
| SCHEMBL7599912 | 0.88 | HTR1A (0.41) | HTR1ADRD3DRD2HTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1255736-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | Boehringer Ingelheim Pharma KG (DE) | 2002-11-13 | — | — | EP | disclosed |
| WO-2001047898-A2 | SUBSTITUTED PIPERAZINE DERIVATIVES AND THEIR USE AS INHIBITORS OF THE MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN (MTP) | BOEHRINGER INGELHEIM PHARMA KG (DE) | 2001-07-05 | — | — | WO | disclosed |