Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.43 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1509435 | 0.74 | AURKA (0.53) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL20532773 | 0.72 | IDO1 (0.54) | HTTALDH1A1MAPK1 | |
| SCHEMBL8796762 | 0.71 | PDGFRB (0.36) | HTTPOLBFGFR1ALDH1A1TP53 | |
| SCHEMBL7472749 | 0.70 | HTT (0.55) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL9025863 | 0.70 | PIK3CB (0.68) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL13052913 | 0.70 | HTT (0.77) | HTTPOLBFGFR1 | |
| SCHEMBL31294902 | 0.69 | HTT (0.62) | HTTFGFR1 | |
| SCHEMBL31049319 | 0.69 | HTT (0.53) | HTTPOLBFGFR1ROCK1MKNK1 | |
| SCHEMBL23900330 | 0.69 | HTT (0.57) | HTTFGFR1 | |
| SCHEMBL547284 | 0.69 | AOC3 (0.37) | ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107459533-B | Benzimidazole-indole skeleton phosphine ligand and preparation method and application thereof | 香港理工大学深圳研究院 | 2020-06-05 | — | — | CN | claimed |
| CN-107459533-B | Benzimidazole-indole skeleton phosphine ligand and preparation method and application thereof | 香港理工大学深圳研究院 | 2020-06-05 | — | — | CN | disclosed |
| EP-0666858-B1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1) AGONISTS | PFIZER (US) | 2001-06-13 | — | — | EP | disclosed |
| EP-1094064-A1 | 5-arylindolederivatives and their use as serotonin(5-ht1)agonists | PFIZER INC. (US) | 2001-04-25 | — | — | EP | disclosed |
| WO-2000078761-A1 | INDOLYL-BENZIMIDAZOLE ANTIBACTERIALS, AND METHODS OF USE THEREOF | SEPRACOR, INC. (US) | 2000-12-28 | — | — | WO | disclosed |
| US-5886008-A | 5-arylindole derivatives | PFIZER INC. (US) | 1999-03-23 | — | — | US | disclosed |
| EP-0666858-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT 1?) AGONISTS | PFIZER INC. (US) | 1995-08-16 | — | — | EP | disclosed |
| WO-1994010171-A1 | 5-ARYLINDOLE DERIVATIVES AND THEIR USE AS SEROTONIN (5-HT1) AGONISTS | PFIZER INC. (US) | 1994-05-11 | — | — | WO | disclosed |