Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MYC | P01106 | 3/20 | 0.55 |
| ▸ | ALPL | P05186 | 2/20 | 0.47 |
| ▸ | PLAA | Q9Y263 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 8/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 8/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 8/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 8/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 8/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 8/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CA4 | P22748 | 1/20 | 0.43 |
| ▸ | CA6 | P23280 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18165572 | 0.87 | MYC (0.54) | MYCALPLPLAAPSEN1PSEN2 | |
| SCHEMBL760545 | 0.84 | USP30 (0.53) | MYCPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL156019 | 0.82 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL29664762 | 0.82 | PSEN1 (0.62) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| Hydrochloric Acid SCHEMBL759650 | 0.81 | PSEN1 (0.61) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL3530849 | 0.81 | NR2E1 (0.45) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL7841275 | 0.80 | PDK1 (0.40) | ALPLPLAAPSEN1PSEN2APH1B | |
| SCHEMBL7935796 | 0.77 | TSHR (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL8060709 | 0.77 | KDM4E (0.43) | PSEN1PSEN2APH1BNCSTNAPH1A | |
| SCHEMBL1757226 | 0.76 | PDE4A (0.59) | KDM4ECA12POLBMAPTCA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | PFIZER INC. (US) | 2012-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120053165-A1 | Novel Phenyl Imidazoles and Phenyl Triazoles As Gamma-Secretase Modulators | BACE1, BACE2, PSEN1 | MYC 2284/4885ALPL 1054/4885PLAA 2324/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.